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International Journal of Endocrinology
Volume 2017 (2017), Article ID 2316986, 6 pages
https://doi.org/10.1155/2017/2316986
Research Article

Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome

1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Białystok, Białystok, Poland
2Department of Reproduction and Gynecological Endocrinology, Medical University of Białystok, Białystok, Poland

Correspondence should be addressed to Agnieszka Adamska; lp.pw@100ka

Received 21 January 2017; Revised 27 April 2017; Accepted 4 May 2017; Published 18 June 2017

Academic Editor: Amelie Bonnefond

Copyright © 2017 Agnieszka Adamska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Diamanti-Kandarakis and A. Dunaif, “Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications,” Endocrine Reviews, vol. 33, no. 6, pp. 981–1030, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Kowalska, M. Straczkowski, A. Nikolajuk et al., “Serum visfatin in relation to insulin resistance and markers of hyperandrogenism in lean and obese women with polycystic ovary syndrome,” Human Reproduction, vol. 22, no. 7, pp. 1824–1829, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Dunaif and D. T. Finegood, “Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome,” The Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 3, pp. 942–947, 1996. View at Publisher · View at Google Scholar
  4. S. A. Arslanian, V. D. Lewy, and K. Danadian, “Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease,” The Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 1, pp. 66–71, 2001. View at Publisher · View at Google Scholar
  5. G. Ren, J. Y. Kim, and C. M. Smas, “Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism,” American Journal of Physiology. Endocrinology and Metabolism, vol. 303, no. 3, pp. E334–E351, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Zhang, “Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels,” Biochemical Biophysical Research Communications, vol. 424, no. 4, pp. 786–792, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. F. Quagliarini, Y. Wang, J. Kozlitina et al., “Atypical angiopoietin-like protein that regulates ANGPTL3,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 48, pp. 19751–19756, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Yi, J. S. Park, and D. A. Melton, “Betatrophin: a hormone that controls pancreatic β cell proliferation,” Cell, vol. 153, no. 4, pp. 747–758, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Li, D. Liu, L. Li et al., “Circulating betatrophin in patients with type 2 diabetes: a meta-analysis,” Journal of Diabetes Research, vol. 2016, Article ID 6194750, p. 9, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Hu, W. Sun, S. Yu et al., “Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients,” Diabetes Care, vol. 37, no. 10, pp. 2718–2722, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Gomez-Ambrosi, E. Pascual, V. Catalan et al., “Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes,” The Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 10, pp. E2004–E2009, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Fenzl, B. K. Itariu, L. Kosi et al., “Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals,” Diabetologia, vol. 57, no. 6, pp. 1204–1208, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Gusarova, C. A. Alexa, E. Na et al., “ANGPTL8/betatrophin does not control pancreatic beta cell expansion,” Cell, vol. 159, no. 3, pp. 691–696, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Abu-Farha, J. Abubaker, I. Al-Khairi et al., “Higher plasma betatrophin/ANGPTL8 level in type 2 diabetes subjects does not correlate with blood glucose or insulin resistance,” Scientific Reports, vol. 5, p. 10949, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Abu-Farha, J. Abubaker, F. Noronha et al., “Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects,” Cardiovascular Diabetology, vol. 14, no. 1, p. 112, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Espes, J. Lau, and P. O. Carlsson, “Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes,” Diabetologia, vol. 57, no. 1, pp. 50–53, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. L. K. Trebotic, P. Klimek, A. Thomas et al., “Circulating betatrophin is strongly increased in pregnancy and gestational diabetes mellitus,” PloS One, vol. 10, no. 9, article e0136701, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Akour, V. Kasabri, N. Boulatova et al., “Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients,” Acta Diabetologica, vol. 54, no. 2, pp. 163–170, 2017. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Al-Rawashdeh, V. Kasabri, N. Bulatova et al., “The correlation between plasma levels of oxytocin and betatrophin in non-diabetic and diabetic metabolic syndrome patients: a cross sectional study from Jordan,” Diabetes and Metabolic Syndrome, vol. 11, no. 1, pp. 59–67, 2017. View at Publisher · View at Google Scholar · View at Scopus
  20. X. Chen, P. Lu, W. He et al., “Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance,” The Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 1, pp. E96–100, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Tokumoto, Y. Hamamoto, K. Fujimoto et al., “Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation tests,” Diabetic Medicine, vol. 32, no. 5, pp. 653–656, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Zhang, S. Li, W. Donelan et al., “Angiopoietin-like protein 8 (betatrophin) is a stress-response protein that down-regulates expression of adipocyte triglyceride lipase,” Biochimica et Biophysica Acta, vol. 1861, no. 2, pp. 130–137, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Wang, F. Quagliarini, V. Gusarova et al., “Mice lacking ANGPTL8 (betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 40, pp. 16109–16114, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group, “Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome,” Fertility and Sterility, vol. 81, no. 1, pp. 19–25, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Vermeulen, L. Verdonck, and J. M. Kaufman, “A critical evaluation of simple methods for the estimation of free testosterone in serum,” The Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 10, pp. 3666–3672, 1999. View at Publisher · View at Google Scholar
  26. D. R. Matthews, J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner, “Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man,” Diabetologia, vol. 28, no. 7, pp. 412–419, 1985. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Matsuda and R. A. DeFronzo, “Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp,” Diabetes Care, vol. 22, no. 9, pp. 1462–1470, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. Z. Fu, F. Yao, A. B. Abou-Samra, and R. Zhang, “Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family,” Biochemical Biophysical Research Communications, vol. 430, no. 3, pp. 1126–1131, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. Z. Fu, F. Berhane, A. Fite, B. Seyoum, A. B. Abou-Samra, and R. Zhang, “Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity,” Scientific Reports, vol. 4, p. 5013, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Calan, O. Yilmaz, T. Kume et al., “Elevated circulating levels of betatrophin are associated with polycystic ovary syndrome,” Endocrine, vol. 53, no. 1, pp. 271–279, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. Q. Qu, D. Zhao, F. Zhang, H. Bao, and Q. Yang, “Serum betatrophin levels are increased and associated with insulin resistance in patients with polycystic ovary syndrome,” Journal of International Medical Research, vol. 45, no. 1, pp. 193–202, 2017. View at Publisher · View at Google Scholar
  32. G. Sahin Ersoy, T. Altun Ensari, D. Vatansever, V. Emirdar, and O. Cevik, “Novel adipokines WISP1 and betatrophin in PCOS: relationship to AMH levels, atherogenic and metabolic profile,” Gynecological Endocrinology, vol. 33, no. 2, pp. 119–123, 2017. View at Publisher · View at Google Scholar · View at Scopus
  33. O. Erol, M. K. Özel, H. Y. Ellidağ, T. Toptaş, A. U. Derbent, and N. Yılmaz, “Assessment of circulating betatrophin concentrations in lean glucose-tolerant women with polycystic ovary syndrome,” Journal of Obstetrics and Gynaecology, pp. 1–6, 2017. View at Publisher · View at Google Scholar
  34. S. Song, J. Wang, C. Guo, and T. Jiang, “Elevated serum levels of betatrophin in patients with polycystic ovary syndrome and the influential factors,” Zhong Nan Da Xue Xue Bao Yi Xue Ban, vol. 41, no. 9, pp. 969–974, 2016. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Li, F. Zhang, J. Cui et al., “Association of betatrophin with metabolic characteristics in overweight/obese and lean women with PCOS,” Gynecological Endocrinology, vol. 33, no. 3, pp. 238–243, 2017. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Erbag, M. Eroglu, H. Turkon et al., “Relationship between betatrophin levels and metabolic parameters in patients with polycystic ovary syndrome,” Cellular and Molecular Biology (Noisy-le-grand, France), vol. 62, no. 5, pp. 20–24, 2016. View at Google Scholar