Serum Concentrations of Betatrophin and Its Association with Indirect Indices of Insulin Resistance and Beta Cell Function in Women with Polycystic Ovary Syndrome
Table 1
Clinical and biochemical characteristics of the studied groups.
Control group ()
PCOS ()
Age (years)
24.3 ± 4.1
25.3 ± 4.5
BMI (kg/m2)
22.8 ± 3.0
24.5 ± 3.1
Waist circumference (cm)
80.3 ± 7.9
85.2 ± 10.7
Hip circumference (cm)
99.7 ± 7.3
101.6 ± 8.4
FFM (kg)
45.5 ± 5.1
46.7 ± 6.0
FM (kg)
18.6 ± 6.6
22.6 ± 7.2
LDL cholesterol (mg/dl)
86.9 ± 20.4
100.5 ± 40.9
TG (mg/dl)
70.4 ± 17.1
78.7 ± 39.7
Glucose 0′ OGTT (mg/dl)
89 ± 6.8
88.2 ± 6.6
Glucose 30′ OGTT (mg/dl)
128.5 ± 24.6
145 ± 28.5
Glucose 60′ OGTT (mg/dl)
97 ± 22.7
123.5 ± 35.8
Glucose 120′ OGTT (mg/dl)
92 ± 15.6
95.7 ± 21.6
Insulin 0′ OGTT (μIU/ml)
11.9 ± 5.5
11.5 ± 4.7
Insulin 30′ OGTT (μIU/ml)
63.7 ± 28.5
89.3 ± 56.7
Insulin 60′ OGTT (μIU/ml)
58.6 ± 49.2
84.4 ± 51.5
Insulin 120′ OGTT (μIU/ml)
35.8 ± 16.9
56.4 ± 49.6
HOMA-IR
2.6 ± 1.2
2.5 ± 1.0
HOMA-B
175.1 ± 80.7
193 ± 186.3
Matsuda index
5.37 ± 1.7
4.8 ± 2.1
Follicle-stimulating hormone (IU/l)
5.8 ± 2.8
4.5 ± 1.4
Luteinizing hormone (IU/l)
3.7 ± 1.3
6.3 ± 3.9
Total testosterone (ng/ml)
0.5 ± 0.2
0.8 ± 0.4
SHBG (nmol/l)
48.0 ± 19.1
45.4 ± 22.6
FAI
4.3 ± 2.2
8.4 ± 5.9
Prolactin (ng/ml)
14.4 ± 6.8
15.2 ± 9.0
Betatrophin 0′ (ng/ml)
0.92 ± 0.35
0.85 ± 0.33
Betatrophin 120′ (ng/ml)
1.15 ± 0.42#
0.88 ± 0.32
Data are presented as mean ± SD. Differences between the groups are derived from nonparametric Mann–Whitney U test. BMI: body mass index; TG: triglycerides; FM: fat mass; FFM: fat-free mass; OGTT: oral glucose tolerance test; HOMA-IR: homeostasis model assessment insulin resistance; HOMA-B: homeostasis model assessment β cell function; FAI: free-androgen index; SHBG: sex hormone-binding globulin; in PCOS women versus control group; # versus the baseline state.
