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International Journal of Endocrinology
Volume 2017 (2017), Article ID 2549491, 6 pages
https://doi.org/10.1155/2017/2549491
Clinical Study

Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Patients with Autoimmune Thyroiditis

Department of Experimental Medicine, University “Sapienza”, Rome, Italy

Correspondence should be addressed to Maurizio Nordio; moc.liamg@1oidronoiziruam

Received 5 July 2016; Revised 27 October 2016; Accepted 21 November 2016; Published 15 February 2017

Academic Editor: Zdravko A. Kamenov

Copyright © 2017 Maurizio Nordio and Sabrina Basciani. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Orgiazzi, “Thyroid autoimmunity,” La Presse Médicale, vol. 41, no. 12, pp. 611–625, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Menconi, A. Hasham, and Y. Tomer, “Environmental triggers of thyroiditis: hepatitis C and interferon-α,” Journal of Endocrinological Investigation, vol. 34, no. 1, pp. 78–84, 2011. View at Publisher · View at Google Scholar
  3. Y. Tomer, “Genetic susceptibility to autoimmune thyroid disease: past, present, and future,” Thyroid, vol. 20, no. 7, pp. 715–725, 2010. View at Publisher · View at Google Scholar
  4. E. Ron and A. Brenner, “Non-malignant thyroid diseases after a wide range of radiation exposures,” Radiation Research, vol. 174, no. 6, pp. 877–888, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. E. C. Somers, S. L. Thomas, L. Smeeth, and A. J. Hall, “Autoimmune diseases co-occurring within individuals and within families: a systematic review,” Epidemiology, vol. 17, no. 2, pp. 202–217, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. A. M. Nada and M. Hammouda, “Immunoregulatory T cells, LFA-3 and HLA-DR in autoimmune thyroid diseases,” Indian Journal of Endocrinology and Metabolism, vol. 18, no. 4, pp. 574–581, 2014. View at Publisher · View at Google Scholar
  7. D. S. Cooper and B. Biondi, “Subclinical thyroid disease,” The Lancet, vol. 379, no. 9821, pp. 1142–1154, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. M. P. Thomas, S. J. Mills, and B. V. Potter, “The ‘other’ inositols and their phosphates: synthesis, biology, and medicine (with recent advances in myo-inositol chemistry),” Angewandte Chemie International Edition, vol. 55, no. 5, pp. 1614–1650, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. T. G. Kutateladze, “Translation of the phosphoinositide code by PI effectors,” Nature Chemical Biology, vol. 6, no. 7, pp. 507–513, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Bizzarri and G. Carlomagno, “Inositol: history of an effective therapy for polycystic ovary syndrome,” European Review for Medical and Pharmacological Sciences, vol. 18, no. 13, pp. 1896–1903, 2014. View at Google Scholar
  11. A. Oetting and P. M. Yen, “New insights into thyroid hormone action,” Best Practice & Research: Clinical Endocrinology & Metabolism, vol. 21, no. 2, pp. 193–208, 2007. View at Google Scholar
  12. J. DeRuiter, “Thyroid hormone tutorial: the thyroid and thyroid hormones,” Endocrine Pharmacotherapy Module: Thyroid Section, Summer, 2001, 2002:5260, pp. 1–16, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. V. Fatourechi, “Demystifying autoimmune thyroid disease. Which disorders require treatment?” Postgraduate Medicine, vol. 107, no. 1, pp. 127–134, 2000. View at Publisher · View at Google Scholar
  14. V. Fatourechi, “Subclinical hypothyroidism: an update for primary care physicians,” Mayo Clinic Proceedings, vol. 84, no. 1, pp. 65–71, 2009. View at Publisher · View at Google Scholar
  15. L. Wartofsky and R. A. Dickey, “The evidence for a narrower thyrotropin reference range is compelling,” The Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 9, pp. 5483–5488, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Gartner, B. C. Gasnier, J. W. Dietrich, B. Krebs, and M. W. Angstwurm, “Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations,” Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 4, pp. 1687–1691, 2002. View at Publisher · View at Google Scholar
  17. J. Köhrle, “Selenium and the thyroid,” Current Opinion in Endocrinology, Diabetes, and Obesity, vol. 20, no. 5, pp. 441–448, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. E. E. Mazokopakis, J. A. Papadakis, M. G. Papadomanolaki et al., “Effects of 12 months treatment with L-selenomethionine on serum anti-TPO levels in patients with Hashimoto’s thyroiditis,” Thyroid, vol. 17, no. 7, pp. 609–612, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Nacamulli, C. Mian, D. Petricca et al., “Influence of physiological dietary selenium supplementation on the natural course of autoimmune thyroiditis,” Clinical Endocrinology, vol. 73, no. 4, pp. 535–539, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. E. N. Pearce, A. P. Farwell, and L. E. Braverman, “Thyroiditis,” The New England Journal of Medicine, vol. 348, no. 26, pp. 2646–2655, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Nordio and R. Pajalich, “Combined treatment with myo-inositol and selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis,” Journal of Thyroid Research, vol. 2013, Article ID 424163, 5 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Nordio and S. Basciani, “Efficacy of a food supplement in patients with Hashimoto thyroiditis,” Journal of Biological Regulators & Homeostatic Agents, vol. 29, no. 1, pp. 93–102, 2015. View at Google Scholar
  23. R. Volpé, “The management of subacute (De Quervain’s) thyroiditis,” Thyroid, vol. 3, no. 3, pp. 253–255, 1993. View at Publisher · View at Google Scholar
  24. A. Pinto and M. Glick, “Management of patients with thyroid disease. Oral health considerations,” The Journal of the American Dental Association, vol. 133, pp. 849–858, 2002. View at Publisher · View at Google Scholar
  25. R. Irvine, “A tale of two inositol trisphosphates,” Biochemical Society Transections, vol. 44, no. 1, pp. 202–211, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. M. J. Iuorno and J. E. Nestler, “The polycystic ovary syndrome: treatment with insulin sensitizing agents,” Diabetes, Obesity & Metabolism, vol. 1, pp. 127–136, 1999. View at Google Scholar
  27. J. Parma, J. van Sande, S. Swillens, M. Tonacchera, J. Dumont, and G. Vassart, “Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3′,5′-monophosphate and inositol phosphate-Ca2+ cascades,” Molecular Endocrinology, vol. 9, no. 6, pp. 725–733, 1995. View at Publisher · View at Google Scholar
  28. S. J. Weiss, N. J. Philp, and E. F. Grollman, “Iodide transport in a continuous line of cultured cells from rat thyroid,” Endocrinology, vol. 114, no. 4, pp. 1090–1098, 1984. View at Publisher · View at Google Scholar
  29. C. U. Pietrzik, J. Hoffmann, K. Stöber et al., “From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 4, pp. 1770–1775, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. X. Li, S. Lu, E. Miyagi, R. Katoh, and A. Kawaoi, “Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells,” Endocrinology, vol. 140, no. 12, pp. 5962–5970, 1999. View at Publisher · View at Google Scholar
  31. H. Kimura, S. Yamashita, H. Namba et al., “Impairment of the TSH signal transduction system in human thyroid carcinoma cells,” Experimental Cell Research, vol. 203, no. 2, pp. 402–406, 1992. View at Publisher · View at Google Scholar · View at Scopus
  32. E. N. Pearce, “In people with subclinical hypothyroidism, TSH level >10 mIU/l may predict increased risk of coronary heart disease and related mortality,” Evidence-Based Medicine, vol. 16, pp. 31–32, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Ochs, R. Auer, D. C. Bauer et al., “Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality,” Annals of Internal Medicine, vol. 148, pp. 832–845, 2008. View at Publisher · View at Google Scholar
  34. M. P. Rayman, “The importance of selenium to human health,” The Lancet, vol. 356, no. 9225, pp. 233–241, 2000. View at Publisher · View at Google Scholar
  35. B. R. Cardoso, B. R. Roberts, A. I. Bush, and D. J. Hare, “Selenium, selenoproteins and neurodegenerative diseases,” Metallomics, vol. 7, no. 8, pp. 1213–1228, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. Huang, A. H. Rose, and P. R. Hoffmann, “The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities,” Antioxidants & Redox Signaling, vol. 16, no. 7, pp. 705–743, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. K. M. Brownand and J. R. Arthur, “Selenium, selenoproteins and human health: a review,” Public Health Nutrition, vol. 4, no. 2, pp. 593–599, 2001. View at Google Scholar
  38. F. Landucci, P. Mancinelli, A. R. De Gaudio, and G. Virgili, “Selenium supplementation in critically ill patients: a systematic review and meta-analysis,” Journal of Critical Care, vol. 29, no. 1, pp. 150–156, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. E. J. van Zuuren Esther, A. Y. Albusta, Z. Fedorowicz, B. Carter, and H. Pijl, “Selenium supplementation for Hashimoto’s thyroiditis,” Cochrane Database of Systematic Reviews, vol. 3, no. 1, pp. 25–31, 2014. View at Publisher · View at Google Scholar · View at Scopus