Efficacy of Once Daily versus Divided Daily Administration of Low Daily Dosage (15 mg/Day) of Methimazole in the Induction of Euthyroidism in Graves’ Hyperthyroidism: A Randomized Controlled Study

Table 3

Cumulative rate of achieving euthyroidism and occurrence of hypothyroidism during treatment with 15 mg/day OD-MMI and 15 mg/day DD-MMI.

	Week 0	Week 2	Week 4	Week 8	Week 12
	Cases (%)	Cases (%)	Cases (%)	Cases (%)	Cases (%)
Euthyroidism
OD-MMI ()	0 (0%)	1 (4.8%)	6 (28.6%)	15 (71.4%)	18 (85.7%)
DD-MMI ()	0 (0%)	1 (4.3%)	8 (34.8%)	19 (82.6%)	20 (87.0%)
Hypothyroidism
OD-MMI ()	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
DD-MMI ()	0	0	3 (13.0%)	1 (4.3%)	0 (0%)

15 mg/day OD-MMI, 15 mg/day of methimazole administered once daily; 15 mg/day DD-MMI, 15 mg/day of methimazole administered dividedly in 5 mg three times a day. No significant difference in rate of achieving euthyroidism between the two treatment regimens. 15 mg/day DD-MMI induced hypothyroidism significantly more than 15 mg/day OD-MMI ().