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International Journal of Endocrinology
Volume 2017, Article ID 2671692, 5 pages
Research Article

Obese Children with Metabolic Syndrome Have 3 Times Higher Risk to Have Nonalcoholic Fatty Liver Disease Compared with Those without Metabolic Syndrome

1Department of Health Sciences, CNHS, Zayed University, Abu Dhabi, UAE
22nd Department of Pediatrics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
3Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus

Correspondence should be addressed to Dimitrios Papandreou;

Received 24 May 2017; Accepted 16 July 2017; Published 8 October 2017

Academic Editor: Faidon Magkos

Copyright © 2017 Dimitrios Papandreou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods. Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results. Forty-four children (58.6%) were found to have MS. Insulin resistance was present in 78 (62.4%) children. Patients with MS were more likely to have NAFLD (). Children with NAFLD had significantly higher body mass index, waist circumference, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal livers (). Insulin resistance was significantly higher in children with NAFLD (). Obese children presenting with MS were 3.01 (2.87–3.57, ) times more likely to develop NAFLD compared to those without metabolic syndrome after adjustment of cofounders. Conclusions. Obese children with MS have a higher risk of developing NAFLD. Weight management and early prevention should be the first line of treatment to prevent any possible health issues later on.