Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2017, Article ID 3848545, 7 pages
https://doi.org/10.1155/2017/3848545
Research Article

Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

Correspondence should be addressed to Sandro La Vignera; ti.tcinu@arengivalordnas

Received 30 December 2016; Revised 13 February 2017; Accepted 28 February 2017; Published 30 March 2017

Academic Editor: Małgorzata Kotula-Balak

Copyright © 2017 Sandro La Vignera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Comhaire, G. Verschraegen, and L. Vermeulen, “Diagnosis of accessory gland infection and its possible role in male infertility,” International Journal of Andrology, vol. 3, no. 1, pp. 32–45, 1980. View at Publisher · View at Google Scholar
  2. K. Everaert, A. Mahmoud, C. Depuydt, M. Maeyaert, and F. Comhaire, “Chronic prostatitis and male accessory gland infection—is there an impact on male infertility (diagnosis and therapy)?” Andrologia, vol. 35, no. 5, pp. 325–330, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. S. La Vignera, R. A. Condorelli, E. Vicari, V. Favilla, G. Morgia, and A. E. Calogero, “Acquired premature ejaculation and male accessory gland infection: relevance of ultrasound examination,” Asian Journal of Andrology, vol. 18, no. 5, pp. 769–772, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. S. La Vignera, “Male accessory gland infections: anatomical extension of inflammation and severity of symptoms evaluated by an original questionnaire,” Andrologia, vol. 44, Supplement 1, pp. 739–746, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. S. La Vignera, A. E. Calogero, R. A. Condorelli et al., “Ultrasonographic evaluation of patients with male accessory gland infection,” Andrologia, vol. 44, Supplement 1, pp. 26–31, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. R. C. Rosen, J. C. Cappelleri, M. D. Smith, J. Lipsky, and B. M. Peña, “Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction,” International Journal of Impotence Research, vol. 11, no. 6, pp. 319–326, 1999. View at Publisher · View at Google Scholar
  7. World Health Organization, WHO Laboratory Manual for the Examination and Processing of Human Semen, Cambridge University Press, Cambridge, UK, 5 edition, 2010.
  8. S. J. Grimsley, M. H. Khan, and G. E. Jones, “Mechanism of phosphodiesterase 5 inhibitor relief of prostatitis symptoms,” Medical Hypotheses, vol. 69, no. 1, pp. 25–26, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Sairam, E. Kulinskaya, T. A. McNicholas, G. B. Boustead, and D. C. Hanbury, “Sildenafil influences lower urinary tract symptoms,” BJU International, vol. 90, no. 9, pp. 836–839, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. A. L. Burnett, M. P. Maguire, S. L. Chamness et al., “Characterization and localization of nitric oxide synthase in the human prostate,” Urology, vol. 45, no. 3, pp. 435–439, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Takeda, R. Tang, E. Shapiro, A. L. Burnett, and H. Lepor, “Effects of nitric oxide on human and canine prostates,” Urology, vol. 45, no. 3, pp. 440–446, 1995. View at Publisher · View at Google Scholar · View at Scopus
  12. R. S. Kirby, D. Lowe, M. I. Bultitude, and K. E. Shuttleworth, “Intra-prostatic urinary reflux: an aetiological factor in abacterial prostatitis,” British Journal of Urology, vol. 54, no. 6, pp. 729–731, 1982. View at Publisher · View at Google Scholar · View at Scopus
  13. R. S. Kirby, C. Carson 3rd, and P. Dasgupta, “Daily phosphodiesterase type 5 inhibitor therapy: a new treatment option for prostatitis/prostatodynia?” BJU International, vol. 113, no. 5, pp. 694–695, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Liguori, C. Trombetta, G. De Giorgi et al., “Efficacy and safety of combined oral therapy with tadalafil and alfuzosin: an integrated approach to the management of patients with lower urinary tract symptoms and erectile dysfunction. Preliminary report,” The Journal of Sexual Medicine, vol. 6, no. 2, pp. 544–552, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. A. A. Eid, F. M. Badr El Dine, and I. M. Nabil, “Histopathologic and ultrastructural changes in seminiferous tubules of adult male albino rats following daily administration of different doses of tadalafil,” Urology, vol. 90, pp. 89–96, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Pomara, G. Morelli, D. Canale et al., “Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men,” Fertility and Sterility, vol. 88, no. 4, pp. 860–865, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Wayman, S. Phillips, C. Lunny et al., “Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology,” International Journal of Impotence Research, vol. 17, no. 3, pp. 216–223, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. W. J. Hellstrom, J. W. Overstreet, A. Yu et al., “Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones,” The Journal of Urology, vol. 170, no. 3, pp. 887–891, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Corvasce, G. Albino, T. Leonetti, A. F. Buonomo, and E. C. Marucco, “Once-a-day tadalafil administration improves the spermogram parameters in fertile patients,” Archivio Italiano di Urologia, Andrologia, vol. 87, no. 3, pp. 210–213, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Vicari, S. La Vignera, R. Castiglione, and A. E. Calogero, “Sperm parameter abnormalities, low seminal fructose and reactive oxygen species overproduction do not discriminate patients with unilateral or bilateral post-infectious inflammatory prostato-vesiculo-epididymitis,” Journal of Endocrinological Investigation, vol. 29, no. 1, pp. 18–25, 2006. View at Publisher · View at Google Scholar
  21. S. La Vignera, “Seminal vesicles of infertile patients with male accessory gland infection: ultrasound evaluation after prolonged treatment with tadalafil, a selective phosphodiesterase-5 inhibitor,” Andrologia, vol. 45, no. 6, pp. 386–391, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. S. La Vignera, E. Vicari, R. Condorelli, R. D'Agata, and A. E. Calogero, “Hypertrophic-congestive and fibro-sclerotic ultrasound variants of male accessory gland infection have different sperm output,” Journal of Endocrinological Investigation, vol. 34, no. 10, pp. e330–e335, 2011. View at Publisher · View at Google Scholar
  23. L. Ozcan, E. C. Polat, E. Onen et al., “Effects of tadalafil 5 mg dosed once daily in men with premature ejaculation,” Urologia Internationalis, vol. 98, no. 2, pp. 210–214, 2017. View at Publisher · View at Google Scholar · View at Scopus
  24. D. A. Paduch, A. Bolyakov, P. K. Polzer, and S. D. Watts, “Effects of 12 weeks of tadalafil treatment on ejaculatory and orgasmic dysfunction and sexual satisfaction in patients with mild to severe erectile dysfunction: integrated analysis of 17 placebo-controlled studies,” BJU International, vol. 111, no. 2, pp. 334–343, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. C. P. Ilie, D. L. Mischianu, and R. J. Pemberton, “Painful ejaculation,” BJU International, vol. 99, no. 6, pp. 1335–1339, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Delavierre, L. Sibert, J. Rigaud, and J. J. Labat, “Painful ejaculation,” Progrès en Urologie, vol. 24, no. 7, pp. 414–420, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. R. Knussmann, K. Christiansen, and C. Couwenbergs, “Relations between sex hormone levels and sexual behavior in men,” Archives of Sexual Behavior, vol. 15, no. 5, pp. 429–445, 1986. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Carosa, P. Martini, F. Brandetti et al., “Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels,” Clinical Endocrinology, vol. 61, no. 3, pp. 382–386, 2004. View at Publisher · View at Google Scholar · View at Scopus