Chronic Administration of Tadalafil Improves the Symptoms of Patients with Amicrobic MAGI: An Open Study

Table 1

Structured Interview about Male Accessory Gland Infections (SI-MAGI).

(a) Urinary disorders (levels of severity: absent: 0; mild: 1–6; moderate: 7–12; severe: 13–18)

	Question	0	1	2	3
1	Nocturia	0 times	1 time	2 times	>2 times
2	Urinary frequency	Absent	Every 2 hours	<2 hours	Every 1 hour
3	Strength of the urinary stream	Regular	Occasional difficulty	Constant difficulty	Constant difficulty and; weakening voided urine
4	Quality of urinary stream	Regular	With intervals	Irregular and continuous	Post micturition drip
5	Failure to empty the bladder	Absent	Episodic	Frequent (>50%)	Constant
6	Duration of symptoms	Absent	<1 month	1–3 months	>3 months

(b) Spontaneous and/or ejaculatory pain or discomfort (levels of severity: absent: 0; mild: 1–8; moderate: 9–16; severe: 17–24)

	Item	0	1	2	3
1	Perineal area	Absent	Occasional and/or; <3 months	>50% or >3 months	Constant and by more than; 3 months
2	Inguinal area	Absent	Occasional and/or; <3 months	>50% or >3 months	Constant and by more than; 3 months
3	Scrotal area	Absent	Occasional and/or; <3 months	>50% or >3 months	Constant and by more than; 3 months
4	Penile area	Absent	Occasional and/or; <3 months	>50% or >3 months	Constant and by more than; 3 months
5	Coccyx area	Absent	Occasional and/or; <3 months	>50% or >3 months	Constant and by more than; 3 months
6	Suprapubic area	Absent	Occasional and/or; <3 months	>50% or >3 months	Constant and by more than; 3 months
7	Irregular bowel and/or diarrhea; and/or hematochezia	Absent	Presence of <1 symptom; and/or sign	Presence of 2 symptoms/signs	Presence of 3 symptoms/signs
8	Duration of symptoms	Absent	<1 month	1–3 months	>3 months

(c) Sexual function (levels of severity: absent: 0; mild: 1–11; moderate: 12–22; severe: 23–33)

	Item	0	1	2	3
1	Reduction of libido	Absent	Occasional and/or >3 months	>50% and/or >3 months	Constant and/or >3 months
2	Erectile dysfunction (achievement)	Absent	Occasional and/or >3 months	>50% and/or >3 months	Constant and/or >3 months
3	Erectile dysfunction (maintenance)	Absent	Occasional and/or >3 months	>50% and/or >3 months	Constant and/or >3 months
4	Difficulties in the second report	Absent	Occasional and/or >3 months	>50% and/or >3 months	Constant and/or >3 months
5	Premature ejaculation	Absent	Occasional and/or >3 months	>50% and/or >3 months	Constant and/or >3 months
6	Delayed ejaculation	Absent	Occasional and/or >3 months	>50% and/or >3 months	Constant and/or >3 months
7	Alteration of the macroscopic character of the ejaculate	Absent	One of the following: stringy, yellow or red-brown, volume reduction	Two of the following: stringy, yellow or red-brown, volume reduction	All of the following: stringy, yellow or red-brown, volume reduction
8	Painful ejaculation	Absent	Episodic	Frequent (>50%)	Constant
9	Ejaculate emission	Absent	Occasionally weakened	Weakened >50% of the time	Increasingly weakened
10	Prostatorrhea	Absent	Episodic	Frequent (>50%)	Constant
11	Hyperspermia	Absent	Episodic	Frequent (>50%)	Constant

(d) Quality of life (levels of severity: absent: 0; mild: 1–5; moderate: 6–10; severe: 11–15)

	Item	0	1	2	3
1	Quality of life associated with; the onset of symptoms	Like before	Satisfactions and failures	Frustrating and/or; use of psychoanalysis	Terrible with recourse to; psychoanalysis and/or drugs
2	Life changes associated with; the onset of symptoms	Absent	Few	Several	Several and important
3	School or work days lost	0	1 day per month	2 days a month	> 2 days per month
4	Quality of married life since it; began a diagnostic evaluation; and/or treatment	Like before	Satisfactions and failures	Frustrating and/or use; of psychoanalysis	Terrible with recourse to; psychoanalysis and/or drugs
5	Infertility duration	<1 year	1-2 years	3-4 years	>4 years

(e) Ultrasound criteria of MAGI

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Prostatitis is suspected in the presence of >2 of the following ultrasonographic signs:

(1) asymmetry of the gland volume; (2) areas of low echogenicity; (3) areas of high echogenicity; (4) dilatation of periprostatic venous plexus; (5) single or multiple internal similar cystitis areas; and (6) area/s of moderate increased of vascularity (focal or multiple).

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Vesiculitis is suspected in the presence of >2 of the following ultrasonographic signs:

(1) increase (>14 mm) anteroposterior diameter mono or bilateral; (2) asymmetry > 2.5 mm (normal 7–14 mm) compared to the contralateral vesicle; (3) reduced (<7 mm) anteroposterior diameter mono or bilateral; (4) glandular epithelium thickened and/or calcified; (5) polycyclic areas separated by hyperechoic septa in one or both vesicles; (6) fundus/body ratio > 2.5; (7) fundus/body ratio < 1; and (8) anteroposterior diameter unchanged after recent immediately ejaculation.

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Epididymitis is suspected in the presence of >2 of the following ultrasonographic signs:

(1) increase in size of the head (craniocaudal diameter > 12 mm) and/or of the tail (craniocaudal diameter > 6 mm) (finding single or bilateral); (2) presence of multiple microcystis in the head and/or tail (finding single or bilateral); (3) low echogenicity or high echogenicity mono or bilateral; (4) large hydrocele mono or bilateral; (5) enlargement in the superior part of the cephalic tract and the superior/inferior part ratio > 1; and (6) unchanged anteroposterior diameter of tail after ejaculation.

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