Clinical Study
Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion
Table 2
Blood pressure and RAAS activity before and after lisinopril intervention.
| | Preintervention | Postintervention | Delta | value |
| | With P-HPT, | | SBP, mmHg | 123.7 (15.7) | 117.3 (14.7) | −6.4 | 0.006 | | DBP, mmHg | 74.5 (8.7) | 70.1 (7.7) | −4.4 | 0.003 | | MAP, mmHg | 92.7 (12.4) | 86.8 (11.1) | −5.9 | 0.002 | | Supine serum aldosterone, ng/dL | 4.6 (3.0) | 4.3 (3.2) | −0.3 | 0.50 | | PRA, ng/mL·hr | 0.5 (0.4) | 1.9 (2.7) | +1.5 | 0.06 | | Aldosterone-to-renin ratio | 26.3 (39.0) | 26.2 (40.5) | −0.15 | 0.98 | | 24 h urinary aldosterone excretion rate, ng/dL·μg/TV | 11.7 (18.3) | 7.8 (8.9) | −3.9 | 0.22 | | 24 h urinary sodium excretion, mmol/day | 239.8 (59.1) | 239.6 (94.1) | −0.2 | 0.99 | | Without P-HPT, | | SBP, mmHg | 117.4 (15.1) | 108.2 (12.2) | −9.2 | <0.0001 | | DBP, mmHg | 72.1 (11.2) | 66.3 (9.3) | −5.8 | 0.0002 | | MAP, mmHg | 87.7 (12.6) | 79.9 (9.7) | −7.8 | 0.003 | | Supine serum aldosterone, ng/dL | 3.4 (1.6) | 4.7 (5.0) | +1.3 | 0.26 | | PRA, ng/mL·hr | 0.5 (0.4) | 4.4 (6.1) | +3.9 | 0.02 | | Aldosterone-to-renin ratio | 13.6 (11.7) | 4.2 (5.5) | −9.4 | 0.0002 | | 24 h urinary aldosterone excretion rate, ng/dL·μg/TV | 5.7 (3.5) | 6.1 (9.1) | +0.4 | 0.86 | | 24 h urinary sodium excretion, mmol/day | 231.9 (82.2) | 203.4 (74.9) | −28.5 | 0.21 |
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Values are mean (SD) unless otherwise noted. values are paired t-tests. RAAS: renin-angiotensin-aldosterone system; HPT: hyperparathyroidism; SBP: systolic blood pressure; DBP: diastolic blood pressure; MAP: mean arterial pressure; PRA: plasma renin activity.
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