Review Article

Male Hypogonadism and Osteoporosis: The Effects, Clinical Consequences, and Treatment of Testosterone Deficiency in Bone Health

Table 2

Comparison of BMD and fracture risk associations of sex steroids and SHBG from large studies.

Fracture riskBMD
TestosteroneEstrogenSHBGTestosteroneEstrogenSHBG
StudyCharacteristicsHVOHVOHVOHVOHVOHVO

CHAMPObservational study
958 Australian men over 70
5-year follow-up
NNNNYYYYY

DubboObservational study
609 Australian men over 60
Average follow-up of 5.8 years
YNNNNNY

LASAObservational study
623 Dutch men over 55
Follow-up 3–6 years
NYYY

TromsøObservational study
3564 Norwegian men and women
aged 25 to 84 (avg age 60)
Average follow-up of 6.5 years
Y

FraminghamProspective cohort study
405 men aged 68 to 96
Hypogonadal men ( ng/mL)
versus eugonadal men
NNYY

mROS SwedenObservational study
3014 Swedish men aged 69–80
Average follow-up of 3.32 years
NNNYYYYNY

mROS USObservational study
1234 men over 65
Average follow-up of 4.6 years
NYY

mROS USObservational study
1436 American men over 65
Average follow-up of 4.7 years
NNNYYY

mROS Hong KongObservational study
1498 men over 65 from Hong Kong
Average follow-up of 4 years
NNNYNNNNYYNN

RotterdamProspective case-control study
179 men over 55 from Rotterdam
Average follow-up of 6.5 years
NN

EPIC-OxfordProspective cohort study
155 men from Oxford avg age 51
6-year follow-up period
NYN

Y denotes statistically significant association; N denotes no association; – indicates not studied. H = hip, V = vertebral, and O = other sites not including hip or vertebral. represents analysis was only univariate and not multivariate.