Table of Contents Author Guidelines Submit a Manuscript
International Journal of Endocrinology
Volume 2017, Article ID 4832608, 8 pages
https://doi.org/10.1155/2017/4832608
Research Article

Serum-Free Thyroxine Levels Were Associated with Pulmonary Hypertension and Pulmonary Artery Systolic Pressure in Euthyroid Patients with Coronary Artery Disease

Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China

Correspondence should be addressed to Yan Ling; moc.361@naygnilrotcod and Xin Gao; moc.621@odne_nahsgnohz

Received 16 August 2016; Revised 19 April 2017; Accepted 24 April 2017; Published 22 June 2017

Academic Editor: Carlo Cappelli

Copyright © 2017 Bingjie Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. B. Badesch, K. M. Wynne, S. Bonvallet, N. F. Voelkel, C. Ridgway, and B. M. Groves, “Hypothyroidism and primary pulmonary hypertension: an autoimmune pathogenetic link?” Annals of Internal Medicine, vol. 119, no. 1, pp. 44–46, 1993. View at Publisher · View at Google Scholar
  2. A. L. Curnock, R. A. Dweik, B. H. Higgins, B. H. Higgins, H. F. Saadi, and A. C. Arroliga, “High prevalence of hypothyroidism in patients with primary pulmonary hypertension,” The American Journal of the Medical Sciences, vol. 318, no. 5, pp. 289–292, 1999. View at Google Scholar
  3. J. W. Chu, P. N. Kao, J. L. Faul, and R. L. Doyle, “High prevalence of autoimmune thyroid disease in pulmonary arterial hypertension,” Chest, vol. 122, no. 5, pp. 1668–1673, 2002. View at Google Scholar
  4. J. H. Li, R. E. Safford, J. F. Aduen, M. G. Heckman, J. E. Crook, and C. D. Burger, “Pulmonary hypertension and thyroid disease,” Chest, vol. 132, no. 3, pp. 793–797, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Marvisi, P. Zambrelli, M. Brianti, G. Civardi, R. Lampugnani, and R. Delsignore, “Pulmonary hypertension is frequent in hyperthyroidism and normalizes after therapy,” European Journal of Internal Medicine, vol. 17, no. 4, pp. 267–271, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Armigliato, R. Paolini, S. Aggio et al., “Hyperthyroidism as a cause of pulmonary arterial hypertension: a prospective study,” Angiology, vol. 57, no. 5, pp. 600–606, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Yazar, O. Doven, S. Atis et al., “Systolic pulmonary artery pressure and serum uric acid levels in patients with hyperthyroidism,” Archives of Medical Research, vol. 34, no. 1, pp. 35–40, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Merce, S. Ferras, C. Oltra et al., “Cardiovascular abnormalities in hyperthyroidism: a prospective Doppler echocardiographic study,” The American Journal of Medicine, vol. 118, no. 2, pp. 126–131, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. C. W. Siu, X. H. Zhang, C. YUNG, A. W. Kung, C. P. Lau, and H. F. Tse, “Hemodynamic changes in hyperthyroidism-related pulmonary hypertension: a prospective echocardiographic study,” The Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 5, pp. 1736–1742, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Marvisi, M. Brianti, G. Marani, R. Del Borello, M. L. Bortesi, and A. Guariglia, “Hyperthyroidism and pulmonary hypertension,” Respiratory Medicine, vol. 96, no. 4, pp. 215–220, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Sugiura, S. Yamanaka, H. Takeuchi, N. Morimoto, M. Kamioka, and Y. Matsumura, “Autoimmunity and pulmonary hypertension in patients with Graves' disease,” Heart and Vessels, vol. 30, no. 5, pp. 642–646, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. M. M. Ciccone, A. Zito, A. Ciampolillo et al., “Pulmonary hypertension and Hashimoto’s thyroiditis: does a relationship exist?” Endocrine, vol. 48, no. 2, pp. 621–628, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Sahin, L. E. Sade, N. B. Tutuncu et al., “Systolic pulmonary artery pressure and echocardiographic measurements in patients with euthyroid Hashimoto’s thyroiditis,” Journal of Endocrinological Investigation, vol. 32, no. 6, pp. 530–532, 2009. View at Publisher · View at Google Scholar
  14. D. A. Fullerton, S. D. Jones, F. L. Grover, and M. I. RC Jr, “Adenosine effectively controls pulmonary hypertension after cardiac operations,” The Annals of Thoracic Surgery, vol. 61, no. 4, pp. 1118–1123, 1996, discussion 1123-1114. View at Publisher · View at Google Scholar · View at Scopus
  15. J. E. Moller, G. S. Hillis, J. K. Oh, and P. A. Pellikka, “Prognostic importance of secondary pulmonary hypertension after acute myocardial infarction,” The American Journal of Cardiology, vol. 96, no. 2, pp. 199–203, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. B. RISTOW, S. ALI, X. REN, M. A. Whooley, and N. B. Schiller, “Elevated pulmonary artery pressure by Doppler echocardiography predicts hospitalization for heart failure and mortality in ambulatory stable coronary artery disease: the Heart and Soul Study,” Journal of the American College of Cardiology, vol. 49, no. 1, pp. 43–49, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. L. G. Rudski, W. W. Lai, J. Afilalo et al., “Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography,” Journal of the American Society of Echocardiography, vol. 23, no. 7, pp. 685–713, 2010, quiz 786-688. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Kong, X. Shu, L. Dong et al., “Right ventricular regional systolic function and dyssynchrony in patients with pulmonary hypertension evaluated by three-dimensional echocardiography,” Journal of the American Society of Echocardiography, vol. 26, no. 6, pp. 649–656, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Simonneau, M. A. Gatzoulis, I. Adatia et al., “Updated clinical classification of pulmonary hypertension,” Journal of the American College of Cardiology, vol. 62, 25 Supplement, pp. D34–D41, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. K. K. Yeo, T. M. Maddox, E. Carey, R. I. Low, and K. A. Shunk, “Right- and left-sided heart catheterization as a quality marker for catheterization laboratories (from the national veterans affairs clinical assessment reporting and tracking program),” The American Journal of Cardiology, vol. 114, no. 11, pp. 1758–1762, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Zhang, B. K. Kim, Y. Chang et al., “Thyroid hormones and coronary artery calcification in euthyroid men and women,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 9, pp. 2128–2134, 2014. View at Publisher · View at Google Scholar
  22. E. S. Kim, J. A. SHIN, J. Y. SHIN et al., “Association between low serum free thyroxine concentrations and coronary artery calcification in healthy euthyroid subjects,” Thyroid, vol. 22, no. 9, pp. 870–876, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Ertas, H. Kaya, and M. S. Soydinc, “Low serum free triiodothyronine levels are associated with the presence and severity of coronary artery disease in the euthyroid patients: an observational study,” Anadolu Kardiyoloji Dergisi, vol. 12, no. 7, pp. 591–596, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Kasahara, K. Tsunekawa, K. Seki, M. Mori, and M. Murakami, “Regulation of iodothyronine deiodinase and roles of thyroid hormones in human coronary artery smooth muscle cells,” Atherosclerosis, vol. 186, no. 1, pp. 207–214, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Al Husseini, G. Bagnato, L. Farkas et al., “Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats,” The European Respiratory Journal, vol. 41, no. 1, pp. 104–114, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. J. Lai, G. J. Chang, Y. H. Yeh, J. H. Pang, C. C. Huang, and W. J. Chen, “Propylthiouracil attenuates experimental pulmonary hypertension via suppression of pen-2, a key component of gamma-secretase,” PloS One, vol. 10, no. 9, article e0137426, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. F. B. Davis, S. A. Mousa, L. O'Connor et al., “Proangiogenic action of thyroid hormone is fibroblast growth factor-dependent and is initiated at the cell surface,” Circulation Research, vol. 94, no. 11, pp. 1500–1506, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. G. L. Roef, Y. E. Taes, J. M. Kaufman et al., “Thyroid hormone levels within reference range are associated with heart rate, cardiac structure, and function in middle-aged men and women,” Thyroid, vol. 23, no. 8, pp. 947–954, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. V. O. Kheyfets, L. Rios, T. Smith et al., “Patient-specific computational modeling of blood flow in the pulmonary arterial circulation,” Computer Methods and Programs in Biomedicine, vol. 120, no. 2, pp. 88–101, 2015. View at Publisher · View at Google Scholar · View at Scopus
  30. D. R. Silva, M. B. Gazzana, A. B. John, D. R. Siqueira, A. L. Maia, and S. S. Barreto, “Pulmonary arterial hypertension and thyroid disease,” Jornal Brasileiro de Pneumologia, vol. 35, no. 2, pp. 179–185, 2009. View at Google Scholar
  31. P. Trip, E. J. Nossent, F. S. De Man et al., “Severely reduced diffusion capacity in idiopathic pulmonary arterial hypertension: patient characteristics and treatment responses,” The European Respiratory Journal, vol. 42, no. 6, pp. 1575–1585, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Santos, V. I. Peinado, J. Ramirez et al., “Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD,” The European Respiratory Journal, vol. 19, no. 4, pp. 632–638, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. K. A. Hale, S. L. Ewing, B. A. Gosnell, and D. E. Niewoehner, “Lung disease in long-term cigarette smokers with and without chronic air-flow obstruction,” The American Review of Respiratory Disease, vol. 130, no. 5, pp. 716–721, 1984. View at Publisher · View at Google Scholar
  34. V. I. Peinado, J. A. Barbera, P. Abate et al., “Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease,” American Journal of Respiratory and Critical Care Medicine, vol. 159, Part 1, no. 5, pp. 1605–1611, 1999. View at Publisher · View at Google Scholar
  35. S. Keusch, F. F. Hildenbrand, T. Bollmann et al., “Tobacco smoke exposure in pulmonary arterial and thromboembolic pulmonary hypertension,” Respiration, vol. 88, no. 1, pp. 38–45, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. C. E. Dagli, H. Sayarlioglu, E. Dogan et al., “Prevalence of and factors affecting pulmonary hypertension in hemodialysis patients,” Respiration, vol. 78, no. 4, pp. 411–415, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. E. M. Moreira, H. Gall, M. J. Leening et al., “Prevalence of pulmonary hypertension in the general population: the Rotterdam Study,” PloS One, vol. 10, no. 6, article e0130072, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. V. Fayngersh, F. Drakopanagiotakis, M. F. Dennis, and J. R. Klinger, “Pulmonary hypertension in a stable community-based COPD population,” Lung, vol. 189, no. 5, pp. 377–382, 2011. View at Publisher · View at Google Scholar · View at Scopus
  39. C. S. Lam, B. A. Borlaug, G. C. Kane, F. T. Enders, R. J. Rodeheffer, and M. M. Redfield, “Age-associated increases in pulmonary artery systolic pressure in the general population,” Circulation, vol. 119, no. 20, pp. 2663–2670, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. B. M. Mcquillan, M. H. Picard, M. Leavitt, and A. E. Weyman, “Clinical correlates and reference intervals for pulmonary artery systolic pressure among echocardiographically normal subjects,” Circulation, vol. 104, no. 23, pp. 2797–2802, 2001. View at Publisher · View at Google Scholar
  41. A. D'Andrea, R. Naeije, E. Grunig et al., “Echocardiography of the pulmonary circulation and right ventricular function: exploring the physiologic spectrum in 1,480 normal subjects,” Chest, vol. 145, no. 5, pp. 1071–1078, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Constantinescu, S. L. Magda, R. Niculescu et al., “New echocardiographic tehniques in pulmonary arterial hypertension vs. right heart catheterization - a pilot study,” Maedica (Buchar), vol. 8, no. 2, pp. 116–123, 2013. View at Google Scholar
  43. J. A. Mazurek and P. R. Forfia, “Enhancing the accuracy of echocardiography in the diagnosis of pulmonary arterial hypertension: looking at the heart to learn about the lungs,” Current Opinion in Pulmonary Medicine, vol. 19, no. 5, pp. 437–445, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. Y. Xie, B. M. Burke, A. Kopelnik et al., “Echocardiographic estimation of pulmonary vascular resistance in chronic thromboembolic pulmonary hypertension: utility of right heart Doppler measurements,” Echocardiography, vol. 31, no. 1, pp. 29–33, 2014. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Lindqvist, S. Soderberg, M. C. Gonzalez, E. Tossavainen, and M. Y. Henein, “Echocardiography based estimation of pulmonary vascular resistance in patients with pulmonary hypertension: a simultaneous Doppler echocardiography and cardiac catheterization study,” European Journal of Echocardiography, vol. 12, no. 12, pp. 961–966, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. M. D'Alto, E. Romeo, P. Argiento et al., “Accuracy and precision of echocardiography versus right heart catheterization for the assessment of pulmonary hypertension,” International Journal of Cardiology, vol. 168, no. 4, pp. 4058–4062, 2013. View at Publisher · View at Google Scholar · View at Scopus