The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause

Table 3

Preclinical studies on endometrial tissue.

	Model	Results
Peano et al. [26]	Ovariectomized mice	(i) BZA, in contrast to RLX or LAS, antagonized the increase in uterine wet weight to levels similar to that induced by vehicle
Oliva et al. [28]	Ovariectomized mitosis—luciferase mice	(i) BZA and CE completely inhibited the proliferative effects of CE in the uterus
Kharode et al. [29]	Ovariectomized rats	(i) BZA/CE inhibited CE-induced uterine stimulation
Komm and Lyttle [22]	Ovariectomized rats	(i) BZA/CE reduced CE-induced uterine wet weight increase in a dose-dependent manner
Ethun et al. [30]	Ovariectomized cynomolgus macaques	(i) Endometrial and epithelial proliferations were significantly reduced with BZA/CE in comparison with CE alone (); (ii) Endometrial hyperplasia rate following BZA/CE treatment was comparable to controls