International Journal of Endocrinology / 2017 / Article / Tab 3

Review Article

The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause

Table 3

Preclinical studies on endometrial tissue.

ModelResults

Peano et al. [26]Ovariectomized mice(i) BZA, in contrast to RLX or LAS, antagonized the increase in uterine wet weight to levels similar to that induced by vehicle
Oliva et al. [28]Ovariectomized mitosis—luciferase mice(i) BZA and CE completely inhibited the proliferative effects of CE in the uterus
Kharode et al. [29]Ovariectomized rats(i) BZA/CE inhibited CE-induced uterine stimulation
Komm and Lyttle [22]Ovariectomized rats(i) BZA/CE reduced CE-induced uterine wet weight increase in a dose-dependent manner
Ethun et al. [30]Ovariectomized cynomolgus macaques(i) Endometrial and epithelial proliferations were significantly reduced with BZA/CE in comparison with CE alone ()
(ii) Endometrial hyperplasia rate following BZA/CE treatment was comparable to controls

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