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International Journal of Endocrinology
Volume 2017, Article ID 5438157, 9 pages
https://doi.org/10.1155/2017/5438157
Clinical Study

The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices

1Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
2Department of Pharmaceutical and Biomedical Sciences, University of Georgia College of Pharmacy, Athens, GA, USA

Correspondence should be addressed to Ran Cui; moc.361@2711nariuc and Shen Qu; moc.liamtoh@ncnehsuq

Received 20 July 2016; Revised 8 November 2016; Accepted 27 November 2016; Published 7 March 2017

Academic Editor: Andre Pascal Kengne

Copyright © 2017 Cuiling Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Chizyński and M. Rózycka, “Hyperuricemia,” Polski Merkuriusz Lekarski, vol. 19, no. 113, pp. 693–696, 2005. View at Google Scholar
  2. D. Conen, V. Wietlisbach, P. Bovet et al., “Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country,” BMC Public Health, vol. 4, article 9, 2004. View at Publisher · View at Google Scholar
  3. Y. Zhu, B. J. Pandya, and H. K. Choi, “Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition,” Arthritis & Rheumatism, vol. 63, no. 10, pp. 3136–3141, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. T. S. Perlstein, O. Gumieniak, G. H. Williams et al., “Uric acid and the development of hypertension: the normative aging study,” Hypertension, vol. 48, no. 6, pp. 1031–1036, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Dehghan, M. van Hoek, E. J. Sijbrands, A. Hofman, and J. C. Witteman, “High serum uric acid as a novel risk factor for type 2 diabetes,” Diabetes Care, vol. 31, no. 2, pp. 361–362, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Yang, C. H. Chu, C. H. Bai et al., “Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study,” Atherosclerosis, vol. 220, no. 2, pp. 525–531, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. C. F. Kuo, S. F. Luo, L. C. See et al., “Hyperuricaemia and accelerated reduction in renal function,” Scandinavian Journal of Rheumatology, vol. 40, no. 2, pp. 116–121, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. S. D. Lin, D. H. Tsai, and S. R. Hsu, “Association between serum uric acid level and components of the metabolic syndrome,” Journal of the Chinese Medical Association, vol. 69, no. 11, pp. 512–516, 2006. View at Publisher · View at Google Scholar
  9. M. Liu, Y. He, B. Jiang et al., “Association between serum uric acid level and metabolic syndrome and its sex difference in a Chinese community elderly population,” International Journal of Endocrinology, vol. 2014, Article ID 754678, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. S. K. Sah, S. Khatiwada, S. Pandey et al., “Association of high-sensitivity C-reactive protein and uric acid with the metabolic syndrome components,” Springerplus, vol. 5, article 269, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. C. A. Stuart, C. R. Gilkison, M. M. Smith, A. M. Bosma, B. S. Keenan, and M. Nagamani, “Acanthosis nigricans as a risk factor for non-insulin dependent diabetes mellitus,” Clinical Pediatrics, vol. 37, no. 2, pp. 73–79, 1998. View at Publisher · View at Google Scholar
  12. L. H. Jones and M. Ficca, “Is Acanthosis nigricans a reliable indicator for risk of type 2 diabetes?” The Journal of School Nursing, vol. 23, no. 5, pp. 247–251, 2007. View at Publisher · View at Google Scholar
  13. S. Sinha and R. A. Schwartz, “Juvenile Acanthosis nigricans,” Journal of the American Academy of Dermatology, vol. 57, no. 3, pp. 502–508, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. J. P. Burke, D. E. Hale, H. P. Hazuda, and M. P. Stern, “A quantitative scale of Acanthosis nigricans,” Diabetes Care, vol. 22, no. 10, pp. 1655–1659, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. C. A. Stuart, M. M. Smith, C. R. Gilkson, S. Shaheb, and R. M. Stahn, “Acanthosis nigricans among Native Americans: an indicator of high diabetes risk,” American Journal of Public Health, vol. 84, no. 11, pp. 1839–1842, 1994. View at Publisher · View at Google Scholar
  16. C. Gilkson and C. A. Stuart, “Assessment of patients with acanthosis nigricans skin lesion for hyperinsulinaemia, insulin resistance and diabetes risk,” The Nurse Practitioner, vol. 17, no. 2, pp. 26–44, 1992. View at Google Scholar
  17. Y. Huang, J. Yang, Y. Li et al., “FGF21 is associated with Acanthosis nigricans in obese patients,” International Journal of Endocrinology, vol. 2016, Article ID 1658062, 7 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Allard, E. E. Delvin, G. Paradis et al., “Distribution of fasting plasma insulin, free fatty acids, and glucose concentrations and of homeostasis model assessment of insulin resistance in a representative sample of Quebec children and adolescents,” Clinical Chemistry, vol. 49, no. 4, pp. 644–649, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. Q. Zhang, C. Zhang, X. Song et al., “A longitudinal cohort based association study between uric acid level and metabolic syndrome in Chinese Han urban male population,” BMC Public Health, vol. 12, article 419, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. J. K. Lee, J. H. Ryoo, J. M. Choi, and S. K. Park, “Serum uric acid level and the incidence of metabolic syndrome in middle-aged Korean men: a 5-year follow-up study,” Journal of Preventive Medicine and Public Health, vol. 47, no. 6, pp. 317–326, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Babio, M. A. Martínez-González, R. Estruch et al., “Associations between serum uric acid concentrations and metabolic syndrome and its components in the PREDIMED study,” Nutrition, Metabolism, and Cardiovascular Diseases, vol. 25, no. 2, pp. 173–180, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. P. J. Havel, “Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism,” Nutrition Reviews, vol. 63, no. 5, pp. 133–157, 2005. View at Publisher · View at Google Scholar
  23. T. Nakagawa, H. Hu, S. Zharikov et al., “A causal role for uric acid in fructose-induced metabolic syndrome,” American Journal of Physiology—Renal Physiology, vol. 290, no. 3, pp. F625–F631, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Y. Sautin, T. Nakagawa, S. Zharikov, and R. J. Johnson, “Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress,” American Journal of Physiology—Cell Physiology, vol. 293, no. 2, pp. C584–C596, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Mercuro, C. Vitale, E. Cerquetani et al., “Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk,” The American Journal of Cardiology, vol. 94, no. 7, pp. 932–935, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. D. I. Feig, D. H. Kang, and R. J. Johnson, “Uric acid and cardiovascular risk,” The New England Journal of Medicine, vol. 359, no. 17, pp. 1811–1821, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. J. S. Flier, P. Usher, and A. C. Moses, “Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptormediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts,” Proceedings of the National Academy of Sciences of the United States of America, vol. 83, no. 3, pp. 664–668, 1986. View at Publisher · View at Google Scholar
  28. G. L. King, C. R. Kahn, M. M. Rechler, and S. P. Nissley, “Direct demonstration of separate receptors for growth and metabolic activities of insulin and multiplication-stimulation activity (an insulin-like growth factor) using antibodies to the insulin receptor,” The Journal of Clinical Investigation, vol. 66, no. 1, pp. 130–140, 1980. View at Publisher · View at Google Scholar
  29. E. D. Angelantonio, S. N. Bhupathiraju, D. Wormser et al., “Body-mass index and all-cause mortality: individual-participant-datameta-analysis of 239 prospective studies in four continents,” The Lancet, vol. 388, no. 10046, pp. 776–786, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Zhu, Y. Hu, T. Huang et al., “High uric acid directly inhibits insulin signalling and induces insulin resistance,” Biochemical and Biophysical Research Communications, vol. 447, no. 4, pp. 707–714, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. J. V. Norvik, H. M. Storhaug, K. Ytrehus et al., “Overweight modifies the longitudinal association between uric acid and some components of the metabolicsyndrome: the Tromsø study,” BMC Cardiovascular Disorders, vol. 16, no. 1, article 85, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. E. Oda, “Serum uric acid is an independent predictor of metabolic syndrome in a Japanese health screening population,” Heart and Vessels, vol. 29, no. 4, pp. 496–503, 2014. View at Publisher · View at Google Scholar · View at Scopus