International Journal of Endocrinology

Research Article

Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children’s Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations

Table 3

Auxological data and hormonal tests results in GHD children with lower IGF-I bioavailability and in GHD children with higher IGF-I bioavailability.


	GHD children with lower IGF-I bioavailability	GHD children with higher IGF-I bioavailability

Number of children (girls/boys)	14 (6/8)	12 (5/7)
Chronological age (years)	10.24 ± 2.37	11.99 ± 2.42
Height SDS	−2.42 ± 0.48	−2.66 ± 0.63
BMI (kg/m²)	16.54 ± 2.53^b	20.65 ± 3.51^b
BMI SDS for CA	−0.21 ± 1.43^d	0.99 ± 1.31^d
BMI SDS for HA	0.13 ± 1.44^c	1.81 ± 1.55^c
GH_max after clonidine (ng/ml)	7.06 ± 1.88	7.64 ± 1.80
GH_max after glucagon (ng/ml)	4.50 ± 1.56^d	7.33 ± 2.85^d
GH_max during nocturnal profile	8.83 ± 5.41	7.34 ± 3.53
IGF-I (ng/ml)	133.33 ± 54.22^a	243.50 ± 77.79^a
IGF-I SDS	−1.79 ± 0.63^b	−0.67 ± 0.79^b
IGFBP-3 (μg/ml)	4.46 ± 1.17	4.52 ± 1.42
IGF-I/IGFBP-3 molar ratio	0.16 ± 0.07^b	0.32 ± 0.11^b
Triglicerides (mg/dl)	68.14 ± 28.34^d	96.30 ± 34.32^d
Total cholesterol (mg/dl)	169.89 ± 31.15	173.18 ± 37.46
LDL cholesterol (mg/dl)	105.43 ± 22.16	89.78 ± 36.92
HDL cholesterol (mg/dl)	62.17 ± 13.95	59.00 ± 14.98
Ghrelin (pg/ml)	1648.95 ± 657.60^d	1005.64 ± 640.44^d
Leptin (ng/ml)	9.82 ± 8.20	16.06 ± 13.93
Adiponectin (ng/ml)	23.72 ± 6.3^d	15.06 ± 6.18^d
Resistin (ng/ml)	8.70 ± 2.51	10.11 ± 3.18
Glucose 0′ (mg/dl)	84.86 ± 4.49	83.90 ± 10.00
Insulin 0′ (uIU/ml)	5.92 ± 4.43^d	9.07 ± 3.63^d
IRI HOMA	1.36 ± 1.04^d	1.93 ± 0.94^d

Data are presented as the means ± SD. GHD: growth hormone deficiency; SDS: standard deviation score; BMI: body mass index; CA: chronological age; HA: height age; IGF-I: insulin-like growth factor I; IGFBP-3: insulin-like growth factor binding protein 3; LDL-cholesterol: low density lipoprotein-cholesterol; HDL-cholesterol: high density lipoprotein-cholesterol; IRI HOMA: insulin resistance index according to homeostasis model assessment. In the individual rows of the table, the variables designated with the same letters differ significantly from each other with ^a, ^b, ^c, and ^d. One-way analysis of variance (ANOVA) was used for group comparison.