Benefits of Levothyroxine Replacement Therapy on Nonalcoholic Fatty Liver Disease in Subclinical Hypothyroidism Patients
Table 1
Baseline characteristics of participants.
Variables
Significant SCH-LT4 ()
Mild SCH patients
LT4 group ()
Control group ()
value
Age (year)
57.79 ± 8.51
55.04 ± 7.85
56.59 ± 8.31
0.074
Female, n (%)
27 (81.8)
135 (74.6)
115 (77.2)
0.584
BMI (kg/m2)
25.88 ± 3.15
26.12 ± 3.11
25.72 ± 3.58
0.372
Weight (kg)
66.13 ± 10.26
66.46 ± 10.40
65.17 ± 11.24
0.308
WC (cm)
91.53 ± 9.17
90.81 ± 9.44
91.19 ± 10.52
0.675
ALT (IU/L)
18.61 ± 7.67
19.09 ± 9.00
17.20 ± 8.35
0.050
AST (IU/L)
26.12 ± 5.83
26.08 ± 6.80
24.65 ± 5.77
0.057
TC (mmol/L)
5.68 ± 0.93
5.91 ± 1.13
5.70 ± 1.05
0.086
HDL-C (mmol/L)
1.35 ± 0.27
1.41 ± 0.33
1.41 ± 0.32
0.923
LDL-C (mmol/L)
3.37 ± 0.91
3.40 ± 0.82
3.29 ± 0.80
0.222
Non-HDL-C (mmol/L)
4.33 ± 0.92
4.50 ± 1.09
4.29 ± 1.02
0.071
TG (mmol/L)
1.35 (0.78)
1.37 (1.00)
1.38 (1.02)
0.712
SBP (mmHg)
149.13 ± 19.61
149.92 ± 19.81
151.75 ± 23.80
0.435
DBP (mmHg)
82.16 ± 10.34
85.21 ± 11.66
86.01 ± 11.77
0.519
FPG (mmol/L)
6.98 ± 2.93
6.28 ± 1.68
6.34 ± 1.88
0.799
Obesity, n (%)
0.440
Normal (BMI< 24)
10 (30.3)
46 (25.4)
46 (30.9)
Overweight (24 ≤ BMI< 28)
14 (42.4)
92 (50.8)
66 (44.3)
Obese (BMI ≥ 28)
9 (27.3)
43 (23.8)
37 (24.8)
Dyslipidemia, n (%)
22 (66.7)
116 (64.1)
91 (61.1)
0.573
NAFLD, n (%)
16 (48.5)
80 (44.2)
59 (39.6)
0.400
Diabetes, n (%)
9 (27.3)
25 (13.8)
25 (16.8)
0.455
Values for quantitative data are expressed as mean ± standard deviation or median (interquartile range); values for categorical variables are expressed as number (percentage). value for comparing variables between mild SCH-LT4 group and mild SCH-control group. SCH: subclinical hypothyroidism; LT4: levothyroxine; BMI: body mass index; WC: waist circumference; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; non-HDL-C: nonhigh-density lipoprotein cholesterol; TG: triglyceride; SBP: systolic blood pressure; DBP: diastolic blood pressure; FPG: fasting plasma glucose; NAFLD: nonalcoholic fatty liver disease.
