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International Journal of Endocrinology
Volume 2017, Article ID 6180904, 10 pages
https://doi.org/10.1155/2017/6180904
Clinical Study

Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals

1Endocrinology Department, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
2Centre for Eye Research Australia, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, East Melbourne, VIC 3002, Australia
3Box Hill Hospital Eastern Health, Box Hill, VIC 3128, Australia
4Endocrinology Department, The Affiliated Hospital of Guizhou Medical University, Guangyang 550000, China

Correspondence should be addressed to Yanbing Li; moc.621@byl40dsae

Received 24 July 2017; Accepted 30 October 2017; Published 28 December 2017

Academic Editor: Rosaria Meccariello

Copyright © 2017 Juan Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate the relationship between abdominal adipose tissue distribution, β-cell function, and insulin sensitivity (IS) in a Chinese population. Methods. One hundred and eighty-eight healthy subjects (healthy group), 239 with normal glucose, and 1~4 abnormal metabolic traits (metabolic dysfunction group, MD group) and 125 with hyperglycemia (hyperglycemia group) were studied. HOMA-IR, HOMA-B, Matsuda index, early- (I0–30/G0–30) and late-phase (I30–120/G30–120) insulin responses and the corresponding disposition indexes (DI) were calculated. The area of abdominal subcutaneous adipose tissue (ASAT) and visceral adipose tissue (VAT) was measured and the ratio of ASAT to VAT (SVR) was calculated. Results. SVR was correlated positively with Matsuda index in healthy, MD, and hyperglycemia groups, and inversely with HOMA-IR. SVR positively related with both early- and late-phase DI in the healthy group only. In the healthy group, the hyperbolas of I0–30/G0–30 and I30–120/G30–120 versus Matsuda index in the highest quarter of SVR were significantly right shifted compared to those in the lowest (both ). Conclusions. In healthy adults, higher SVR was a protective factor for β-cell function and IS, while in those with glucometabolic abnormality, higher SVR contributed to a relative better IS, indicating SVR is possible to be an early predicator of type 2 diabetes development.