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International Journal of Endocrinology
Volume 2017, Article ID 6969286, 8 pages
https://doi.org/10.1155/2017/6969286
Research Article

Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population

1Neuroendocrine Department, Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
2School of Medicine, University of Belgrade, Belgrade, Serbia
3Institute of Medical Statistics and Informatics, Belgrade, Serbia

Correspondence should be addressed to M. Doknić; moc.liamg@cinkodanajrim

Received 8 January 2017; Accepted 27 March 2017; Published 18 June 2017

Academic Editor: Sabrina Corbetta

Copyright © 2017 M. Doknić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. P. Gutierrez, M. Koltowska-Haggstrom, P. J. Jonsson et al., “Registries as a tool in evidence based medicine: example of KIMS (Pfizer International Metabolic Database),” Pharmacoepidemiology and Drug Safety, vol. 17, pp. 90–102, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Höybye, L. Sävendahl, H. T. Christesen et al., “The NordiNet® International Outcome Study and NovoNet® ANSWER Program®: rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therapy (Norditropin®),” Clinical Epidemiology, vol. 26, pp. 119–127, 2013. View at Google Scholar
  3. A. F. Attanasio, P. C. Bates, K. K. Ho et al., “Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status—3-year results from the HypoCCS Database,” The Journal of Clinical Endocrinology and Metabolism, vol. 87, pp. 1600–1606, 2002. View at Publisher · View at Google Scholar
  4. M. R. Stieg, U. Renner, G. K. Stalla, and A. Kopczak, “Advances in understanding hypopituitarism,” F1000 Research, vol. 6, p. 178, 2017. View at Publisher · View at Google Scholar
  5. M. J. McCabe and M. T. Dattani, “Genetic aspects of hypothalamic and pituitary gland development,” Handbook of Clinical Neurology, vol. 124, pp. 3–15, 2014. View at Google Scholar
  6. S. Birla, R. Khadgawat, V. P. Jyotsna et al., “Identification of novel PROP1 and POU1F1 mutations in patients with combined pituitary hormone deficiency,” Hormone and Metabolic Research, vol. 48, pp. 822–827, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Krewer, M. Schneider, H. J. Schneider et al., “Neuroendocrine disturbances one to five or more years after traumatic brain injury and aneurysmal subarachnoid hemorrhage: data from the German database on hypopituitarism,” Journal of Neurotrauma, vol. 33, pp. 1544–1553, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Kyriakakis, J. Lynch, S. M. Orme et al., “Pituitary dysfunction following cranial radiotherapy for adult-onset nonpituitary brain tumours,” Clinical Endocrinology, vol. 84, pp. 372–379, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Popovic, S. Pekic, D. Pavlovic et al., “Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distress,” Journal of Endocrinological Investigation, vol. 27, pp. 1048–1054, 2004. View at Publisher · View at Google Scholar
  10. H. J. Schneider, I. Kreitschmann-Andermahr, E. Ghigo, G. K. Stalla, and A. Agha, “Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review,” JAMA, vol. 298, pp. 1429–1438, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Tanriverdi and F. Kelestimur, “Neuroendocrine disturbances after brain damage: an important and often undiagnosed disorder,” Journal of Clinical Medicine, vol. 4, pp. 847–857, 2015. View at Publisher · View at Google Scholar
  12. A. W. van der Eerden, M. T. Twickler, F. C. Sweep et al., “Should anterior pituitary function be tested during follow-up of all patients presenting at the emergency department because of traumatic brain injury?” European Journal of Endocrinology, vol. 162, pp. 19–28, 2010. View at Google Scholar
  13. N. E. Kokshoorn, J. W. Smit, W. A. Nieuwlaat et al., “Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study,” European Journal of Endocrinology, vol. 165, pp. 225–231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Klose and U. Feldt-Rasmussen, “Hypopituitarism in traumatic brain injury-a crtical note,” Journal of Clinical Medicine, vol. 4, pp. 1480–1497, 2015. View at Publisher · View at Google Scholar
  15. V. Jovanovic, S. Pekic, M. Stojanovic et al., “Neuroendocrine dysfunction in patients recovering from subarachnoid hemorrhage,” Hormones (Athens, Greece), vol. 9, pp. 235–244, 2010. View at Publisher · View at Google Scholar
  16. L. Khajeh, K. Blijdorp, M. H. Heijenbrok-Kal et al., “Pituitary dysfunction after aneurysmal subarachnoid haemorrhage: course and clinical predictors-the HIPS study,” Journal of Neurology, Neurosurgery, and Psychiatry, vol. 86, pp. 905–910, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Vieira Jr, L. A. de Albuquerque, A. B. de Avellar et al., “Long-term follow-up of anterior pituitary deficiency after aneurysmal subarachnoid hemorrhage: prospective cohort,” Journal of Stroke and Cerebrovascular Diseases, vol. 25, pp. 2405–2414, 2016. View at Publisher · View at Google Scholar · View at Scopus
  18. N. M. Appelman-Dijkstra, N. E. Kokshoorn, O. M. Dekkers et al., “Pituitary dysfunction in adult patients after cranial radiotherapy: systematic review and meta-analysis,” The Journal of Clinical Endocrinology and Metabolism, vol. 96, pp. 2330–2340, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Taku, M. Gurnell, N. Burnet, and R. Jena, “Time dependence of radiation-induced hypothalamic-pituitary axis dysfunction in adults treated for non-pituitary, intracranial neoplasms,” Clinical Oncology (Royal College of Radiologists), vol. 29, pp. 34–41, 2017. View at Publisher · View at Google Scholar
  20. K. H. Darzy, “Radiation-induced hypopituitarism,” Current Opinion in Endocrinology, Diabetes, and Obesity, vol. 20, pp. 342–353, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. V. Popovic, S. Pekic, I. Golubicic, M. Doknic, C. Dieguez, and F. F. Casanueva, “The impact of cranial irradiation on GH responsiveness to GHRH plus GH-releasing peptide-6,” The Journal of Clinical Endocrinology and Metabolism, vol. 87, pp. 2095–2099, 2002. View at Publisher · View at Google Scholar
  22. M. D. Littley, S. M. Shalet, C. G. Beardwell, S. R. Ahmed, G. Applegate, and M. L. Sutton, “Hypopituitarism following external radiotherapy for pituitary tumours in adults,” The Quarterly Journal of Medicine, vol. 70, pp. 145–160, 1989. View at Google Scholar
  23. S. Chiloiro, T. Tartaglione, F. Angelini et al., “An overview of diagnosis of primary autoimmune hypophysitis in a prospective single-center experience,” Neuroendocrinology, vol. 104, pp. 280–290, 2017. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Tsiakalos, I. D. Xynos, N. V. Sipsas, and G. Kaltsas, “Pituitary insufficiency after infectious meningitis: a prospective study,” The Journal of Clinical Endocrinology and Metabolism, vol. 95, pp. 3277–3281, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Dalan and M. K. Leow, “Pituitary abscess: our experience with a case and a review of the literature,” Pituitary, vol. 11, pp. 299–306, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Pekic and V. Popovic, “Alternative causes of hypopituitarism: traumatic brain injury, cranial irradiation, and infections,” Handbook of Clinical Neurology, vol. 124, pp. 271–290, 2014. View at Google Scholar
  27. S. Pekic and V. Popovic, “Diagnosis of endocrine desease: expanding the cause of hypopituitarism,” European Journal of Endocrinology, vol. 176, no. 6, pp. R269–R282, 2017. View at Publisher · View at Google Scholar
  28. J. W. Tomlinson, N. Holden, R. K. Hills et al., “Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group,” Lancet, vol. 357, pp. 425–431, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Sherlock, J. Ayuk, J. W. Tomlinson et al., “Mortality in patients with pituitary disease,” Endocrine Reviews, vol. 1, pp. 301–342, 2013. View at Google Scholar
  30. I. C. van Nieuwpoort, C. C. van Bunderen, L. I. Arwert et al., “Dutch National Registry of GH treatment in adults: patient characteristics and diagnostic test procedures,” European Journal of Endocrinology, vol. 164, pp. 491–497, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Tanriverdi, H. S. Dokmetas, N. Kebapcı et al., “Etiology of hypopituitarism in tertiary care institutions in Turkish population: analysis of 773 patients from Pituitary Study Group database,” Endocrine, vol. 47, pp. 198–205, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. E. Fernandez-Rodriguez, M. Lopez-Raton, P. Andujar et al., “Epidemiology, mortality rate and survival in a homogeneous population of hypopituitary patients,” Clinical Endocrinology, vol. 78, pp. 278–284, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Cheer and P. J. Trainer, “Evaluation of pituitary function,” Handbook of Clinical Neurology, vol. 124, pp. 141–149, 2014. View at Google Scholar
  34. M. E. Molitch, D. R. Clemmons, S. Malozowski, G. R. Merriam, M. L. Vance, and Endocrine Society, “Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline,” The Journal of Clinical Endocrinology and Metabolism, vol. 96, pp. 1587–1609, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Garrahy and A. Agha, “How should we interrogate the hypothalamic-pituitary-adrenal axis in patients with suspected hypopituitarism?” BMC Endocrine Disorders, vol. 16, no. 1, p. 36, 2016. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Stojanovic, S. Pekic, G. Cvijovic et al., “High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndrome,” The Journal of Clinical Endocrinology and Metabolism, vol. 93, pp. 2722–2728, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. A. M. Beatrice, C. Selvan, and S. Mukhopadhyay, “Pituitary dysfunction in infective brain diseases,” Indian Journal of Endocrinology and Metabolism, vol. 17, pp. S608–S611, 2013. View at Publisher · View at Google Scholar
  38. A. Gundgurthi, M. K. Garg, R. Bhardwaj, K. S. Brar, and S. Kharb, “Clinical spectrum of hypopituitarism in India: a single center experience,” Indian Journal of Endocrinology and Metabolism, vol. 6, pp. 803–808, 2012. View at Google Scholar
  39. C. N. Antonypillai, J. A. Wass, D. A. Warrell, and H. N. Rajaratnam, “Hypopituitarism following envenoming by Russell’s vipers (Daboia siamensis and D. russelii) resembling Sheehan’s syndrome: first case report from Sri Lanka, a review of the literature and recommendations for endocrine management,” QJM, vol. 104, pp. 97–108, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. P. Chatterjee, P. Mukhopadhyay, K. Pandit et al., “Profile of hypopituitarism in a tertiary care hospital of eastern India-is quality of life different in patients with growth hormone deficiency?” Journal of the Indian Medical Association, vol. 106, pp. 384-385, 2008. View at Google Scholar
  41. A. Juszczak, A. Gupta, N. Karavitaki, M. R. Middleton, and A. B. Grossman, “Ipilimumab: a novel immunomodulating therapy causing autoimmune hypophysitis: a case report and review,” European Journal of Endocrinology, vol. 167, pp. 1–5, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. G. Brabant, E. M. Poll, P. Jönsson, D. Polydorou, and I. Kreitschmann-Andermahr, “Etiology, baseline characteristics, and biochemical diagnosis of GH deficiency in the adult: are there regional variations?” European Journal of Endocrinology, vol. 161, pp. S25–S31, 2009. View at Google Scholar
  43. A. Shimatsu, S. Tai, T. Tanaka, K. Fujieda, A. Teramoto, and K. Chihara, “Clinical characteristics of Japanese adults with growth hormone deficiency: a HypoCCS database study,” Endocrine Journal, vol. 58, pp. 325–333, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Pekic, V. A. Arsenijevic, M. S. Gazibara et al., “What lurks in the sellar?” Lancet, vol. 375, p. 432, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Stojanović, S. Pekić, M. Doknić et al., “What’s in the image? Pituitary metastasis from papillary carcinoma of the thyroid: a case report and a comprehensive review of the literature,” European thyroid Journal, vol. 1, pp. 277–284, 2013. View at Publisher · View at Google Scholar
  46. B. Harbeck, S. Klose, M. Buchfelder, G. Brabant, and H. Lehnert, “Hypopituitarism in a HIV affected patient,” Experimental and Clinical Endocrinology & Diabetes, vol. 119, pp. 633–635, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. R. Abs, A. F. Mattsson, B. A. Bengtsson et al., “Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients. A sub-analysis of the KIMS database,” Growth Hormone & IGF Research, vol. 15, pp. 349–359, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. S. M. Webb, C. J. Strasburger, D. Mo et al., “Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database,” The Journal of Clinical Endocrinology and Metabolism, vol. 94, pp. 392–399, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Melmed, “Idiopathic adult growth hormone deficiency,” The Journal of Clinical Endocrinology and Metabolism, vol. 98, pp. 2187–2197, 2013. View at Publisher · View at Google Scholar · View at Scopus
  50. V. Wilson, A. Mallipedhi, J. W. Stephens, R. M. Redfern, and D. E. Price, “The causes of hypopituitarism in the absence of abnormal pituitary imaging,” QJM, vol. 107, pp. 21–24, 2014. View at Google Scholar
  51. A. De Bellis, E. Pane, G. Bellastella et al., “Detection of antipituitary and antihypothalamus antibodies to investigate the role of pituitary or hypothalamic autoimmunity in patients with selective idiopathic hypopituitarism,” Clinical Endocrinology, vol. 75, pp. 361–366, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. A. Mehta, P. C. Hindmarsh, H. Mehta et al., “Congenital hypopituitarism: clinical, molecular and neuroradiological correlates,” Clinical Endocrinology, vol. 71, pp. 376–382, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. M. Doknic, S. Pekic, M. Civcic, and V. Popovic, “Clinical case seminar. Peculiar prolactinomas in patients with pituitary developmental gene mutations: from an adult endocrinologist perspective,” Hormones (Athens, Greece), vol. 11, pp. 189–198, 2012. View at Publisher · View at Google Scholar
  54. H. F. Nyström, A. Saveanu, E. J. Barbosa et al., “Detection of genetic hypopituitarism in an adult population of idiopathic pituitary insufficiency patients with growth hormone deficiency,” Pituitary, vol. 14, pp. 208–216, 2011. View at Publisher · View at Google Scholar · View at Scopus