Chronic Hyperinsulinaemic Hypoglycaemia in Rats Is Accompanied by Increased Body Weight, Hyperleptinaemia, and Decreased Neuronal Glucose Transporter Levels in the Brain

Table 1

Overview of study design (a) and doses (b).

(a)

Day 1	Day 29	Day 57	Day R2	Day R29
	Sacrifice	Sacrifice	Sacrifice	Sacrifice
	Infusion		Infusion-free recovery

(b)

Group	n	HI dose during infusion (nmol/kg/day)
CTRL-M/CTRL-F	38/38	0/0
HI-M/HI-F	38/38	72>60/54>48

HI: human insulin, CTRL-M: control group males, CTRL-F: control group females, HI-M: HI-infused males, HI-F: HI-infused females. Doses were lowered day 12 or day 19 due to clinical signs of severe hypoglycaemia and mortalities related to hypoglycaemia. As the animals started infusion in the two cohorts, doses were lowered on two different dosing days.