BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults

Table 1

General, anthropometric, hormonal, and metabolic parameters of the study population.

	18.5 ≤ BMI< 25	BMI ≥ 25	value
	()	()
General characteristics
Age (years)	48.33 ± 9.28	48.64 ± 8.34	0.525
Height (cm)	167.56 ± 7.05	170.61 ± 6.08	<0.001
Body weight (kg)	63.20 ± 8.00	79.52 ± 8.28	<0.001
BMI (kg/m^2)	22.43 ± 1.70	27.28 ± 1.96	<0.001
Lipid profile
TG (mmol/L)	1.27(0.87–1.89)	1.90 (1.32–2.86)	<0.001
Total cholesterol (mmol/L)	4.82 ± 0.96	4.95 ± 0.94	<0.05
HDL cholesterol (mg/L)	13.21 ± 3.34	11.64 ± 2.95	<0.001
LDL cholesterol (mg/L)	29.53 ± 8.18	29.93 ± 8.18	0.386
TSH and thyroid hormones
FT3 (pmol/L)	4.11 ± 0.57	4.29 ± 0.58	<0.001
FT4 (pmol/L)	12.62 ± 1.70	12.41 ± 1.54	<0.05
TSH (mIU/L)	1.66 ± 0.86	1.58 ± 0.85	0.074

Subjects on thyroid medications, with TPO antibodies, anti-thyroglobulin antibodies above clinical cutoff, and with TSH levels outside the reference range, were excluded from further analyses. We stratified the study group according to BMI levels: 18.5 ≤ BMI< 25 kg/m²: normal-weight group; BMI ≥ 25 kg/m²: overweight/obese group. All continuous parameters were presented as mean ± standard deviation. For skewness distribution data, median and interquartile range was used. values were calculated from one-way analysis of variance. BMI: body mass index; FT3: free triiodothyronine; FT4: free thyroxine; TSH: thyrotropin; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein. Significant associations are indicated in bold. was considered statistically significant. ,