CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers

Table 3

Univariate statistical analysis of PD1 and CTLA4 ligand gene expression and PTC patient characteristics and clinicopathological features. For each clinicopathological feature, the number of patients in each group was reported in brackets. For each gene, the median value of mRNA fold change between PTC tissue and its normal counterpart is reported.

	PD-L1	value	PD-L2	value	CD80	value	CD86	value
Gender
Male ()	1.68	0.468	1.48	0.346	0.97	0.210	1.98	0.940
Female ()	1.26		0.99		0.71		1.42
Age (y/o)
Corr. coeff.	0.131	0.209	0.161	0.122	0.141	0.176	−0.003	0.979
Hystology
Classical variant ()	1.41	0.002	1.11	0.033	0.89	0.046	1.57	0.059
Follicular variant ()	1.02		0.52		0.51		1.27
BRAF
Wild type ()	1.21	0.026	0.86	0.035	0.72	0.355	1.21	0.081
V600E ()	1.79		1.41		0.86		1.65
pT
T1-2 ()	1.05	0.060	0.91	0.053	0.63	0.132	1.24	0.040
T3-4 ()	1.52		1.22		0.92		1.78
pN
N0 ()	1.10	0.062	0.80	0.002	0.55	0.010	1.47	0.615
N1 ()	1.37		1.54		1.02		1.48
TNM stage
I-II ()	1.12	0.118	0.97	0.113	0.67	0.077	1.43	0.292
III-IV ()	1.54		1.46		0.95		1.88
Recurrence
No ()	1.28	0.626	1.03	0.903	0.81	0.244	1.39	0.696
Yes ()	1.25		1.03		0.78		1.25
Thyroiditis
No ()	1.34	0.690	1.07	0.892	0.69	0.129	1.68	0.144
Yes ()	1.10		1.03		0.92		1.35