Research Article

Implication of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, and Subclinical Inflammation on Mild Renal Insufficiency

Table 1

Characteristics of study subjects.

NAFLD (−)NAFLD (+) value

788386
Age (years)52 (44, 58)53 (47, 58)0.018
Sex (male, %)297 (37.7)227 (58.8)<0.001
BMI (kg/m2)22.6 (20.8, 24.7)25.2 (23.7, 27.3)<0.001
WC (cm)75 (69, 81)84 (79, 90)<0.001
Systolic BP (mmHg)116 (105, 127)122 (113, 132)<0.001
Diastolic BP (mmHg)75 (68, 84)79 (72, 87)<0.001
Total cholesterol (mg/dL)189 (166, 214)195.5 (171, 223)0.007
Triglyceride (mg/dL)81 (55, 121)129 (91, 192)<0.001
HDL-C (mg/dL)57 (47, 68)48 (41, 55)<0.001
LDL-C (mg/dL)116 (93.5, 141)125 (101, 151)<0.001
Glucose (mg/dL)93 (88, 100)100 (93, 109)<0.001
HbA1c (%)5.3 (5.1, 5.6)5.6 (5.3, 6)<0.001
AST (IU/L)24 (19, 29)27 (22, 34)<0.001
ALT (IU/L)18 (14, 25)27.5 (19, 39)<0.001
hsCRP (mg/L)0.4 (0.2, 1.2)0.8 (0.4, 1.8)<0.001
Creatinine (mg/dL)0.7 (0.6, 0.8)0.8 (0.6, 0.9)<0.001
eGFR (mL/min/1.73 m2)103.9 (92.2, 115.9)97.4 (86.7, 108.3)<0.001
eGFR < 90 mL/min/1.73 m2165 (20.9)119 (30.8)<0.001
Metabolic syndrome (%)107 (13.6)168 (43.5)<0.001
Diabetes mellitus (%)32 (4.1)49 (12.7)<0.001
Hypertension (%)116 (14.7)105 (27.2)<0.001
Current smokers (%)104 (13.2)81 (21.0)<0.001
Alcohol users (%)362 (47.0)171 (45.2)0.571
Regular exercisers (%)298 (38.1)130 (33.9)0.171

Data are presented as median (interquartile range) or (%). BMI, body mass index; WC, waist circumference; BP, blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase, hsCRP, high-sensitivity C-reactive protein; eGFR, estimated glomerular filtration rate.