Clinicopathological and Survival Outcomes of Well-Differentiated Thyroid Carcinoma Undergoing Dedifferentiation: A Retrospective Study from FUSCC

Table 3

Risk factors for decreased disease-free survival in WDTC patients harboring dedifferentiated phenotype.

Variables	Univariate analysis			Multivariate analysis
	value	HR	95.0% CI for HR	value	HR	95.0% CI for HR
Gender
Female		1
Male	0.145	1.805	0.816–3.992
Age	0.002	1.045	1.016–1.076	0.015	1.038	1.007–1.070
Maximum size	0.351	1.105	0.896–1.364
ETE
No		1
Yes	0.630	1.240	0.517–2.977
Histological subtypes of WDTC
FTC		1
PTC	0.150	2.893	0.682–12.278
Dedifferentiated site
Thyroid		1			1
Metastatic site	0.016	2.746	1.210–6.235	0.559	1.312	0.528–3.259
Thyroid and metastatic site	0.250	2.437	0.534–11.109	0.668	1.408	0.296–6.706
Dedifferentiated components
PDTC		1
ATC	0.137	1.941	0.809–4.658
LNM
No		1
Yes	0.092	2.323	0.871–6.197
DM
No		1
Yes	0.003	3.358	1.517–7.432	0.128	1.914	0.829–4.417
Adjuvant therapy
No		1
Yes	0.054	2.249	0.987–5.126

Bold type indicates statistical significance. WDTC: well-differentiated thyroid cancer; HR: hazard ratio; CI: confidence interval; ETE: extrathyroidal extension; FTC: follicular thyroid cancer; PTC: papillary thyroid cancer; PDTC: poorly differentiated thyroid cancer; ATC: anaplastic thyroid cancer; LNM: lymph node metastasis; DM: distant metastasis.