Clinicopathological and Survival Outcomes of Well-Differentiated Thyroid Carcinoma Undergoing Dedifferentiation: A Retrospective Study from FUSCC

Table 4

Comparison of prognostic classification systems in WDTC patients harboring dedifferentiated phenotype.

Prognostic classification system	Percentage of cause-specific survival		C-index	AIC
	5 years (%)	10 years (%)
EORTC			0.722	69.338
I-II	94.7	94.7
III	71.6	71.6
IV	41.0	27.3
V	34.6	34.6
AGES			0.723	59.937
Group 1	100.0	100.0
Group 2	65.6	65.6
Group 3	37.5	37.5
Group 4	42.5	34.0
AMES			0.650	71.915
Low risk	82.0	82.0
High risk	43.5	34.8
MACIS			0.688	68.954
I	88.1	88.1
II	22.2	22.2
III	60.0	60.0
IV	44.9	29.9
TNM stage (7th)			0.669	68.113
I-II	95.8	95.8
III	50.0	50.0
IV	45.9	36.7
TNM stage (8th)			0.719	60.816
I	95.2	95.2
II	37.5	37.5
III	42.9	42.9
IV	44.9	29.9

WDTC: well-differentiated thyroid cancer; C-index: index of concordance; AIC: Akaike information criterion; EORTC: European Organization for Research and Treatment of Cancer; AGES: age, grade, extent, size; AMES: age, metastases, extent, size; MACIS: metastases, age, completeness of resection, invasion, size; TNM: tumor, lymph node, metastasis.