Meta-Analysis of the Association between Vitamin D Receptor Polymorphisms and the Risk of Autoimmune Thyroid Disease

Table 3

The association between VDR rs1544410 polymorphism and AITD risk.

Comparison model	Subgroup	The number of studies	Sample size (cases/controls)	I^2		Effect model	OR (95% CI)
Homozygote comparison (AA versus GG)	AITD	17	2405/2032	57%	0.002	Random	0.74 [0.53, 1.02]	0.07
	HT	8	763/837	34%	0.15	Fixed	0.80 [0.55, 1.16]	0.24
	GD	12	1642/1631	68%	<0.001	Random	0.71 [0.46, 1.09]	0.11
	European	8	959/1076	65%	0.005	Random	0.60 [0.46, 0.93]	0.02
	Asian	8	1400/928	0%	0.47	Fixed	1.51 [0.90, 2.55]	0.12
	African	1	46/28	—	—	—	0.18 [0.06, 0.53]	0.002
		13	1823/1539	62%	0.001	Random	0.66 [0.45, 0.98]	0.04
		4	582/493	28%	0.24	Fixed	1.06 [0.70, 1.61]	0.79
Heterozygote comparison (AG versus GG)	AITD	17	3180/2788	38%	0.05	Random	0.99 [0.84, 1.18]	0.93
	HT	8	925/984	0%	0.63	Fixed	1.07 [0.84, 1.36]	0.61
	GD	12	2255/2285	60%	0.004	Random	0.99 [0.78, 1.25]	0.94
	European	8	1432/1638	0%	0.85	Fixed	0.83 [0.71, 0.97]	0.02
	Asian	8	1666/1110	22%	0.25	Fixed	1.34 [1.08, 1.67]	0.008
	African	1	82/40	—	—	—	0.56 [0.25, 1.23]	0.15
		13	2475/2103	22%	0.22	Fixed	0.95 [0.82, 1.08]	0.42
		4	705/685	71%	0.01	Random	1.32 [0.69, 2.54]	0.41
Dominant model (AA + AG versus GG)	AITD	17	3636/3373	61%	<0.001	Random	0.98 [0.80, 1.20]	0.82
	HT	8	1009/1089	25%	0.23	Fixed	1.03 [0.82, 1.29]	0.82
	GD	12	2627/2769	73%	<0.001	Random	0.97 [0.74, 1.27]	0.81
	European	8	1835/2177	3%	0.41	Fixed	0.79 [0.68, 0.91]	0.002
	Asian	8	1711/1141	44%	0.09	Random	1.41 [1.05, 1.90]	0.02
	African	1	90/55	—	—	—	0.42 [0.20, 0.90]	0.02
		13	2869/2593	56%	0.008	Random	0.91 [0.74, 1.12]	0.38
		4	767/780	77%	0.004	Random	1.39 [0.70, 2.76]	0.34
Recessive model (AA versus AG + GG)	AITD	17	3636/3373	58%	0.002	Random	0.79 [0.59, 1.06]	0.11
	HT	8	1009/1089	35%	0.15	Fixed	0.82 [0.59, 1.13]	0.22
	GD	12	2627/2769	67%	<0.001	Random	0.77 [0.53, 1.12]	0.17
	European	8	1835/2177	71%	0.001	Random	0.74 [0.53, 1.02]	0.06
	Asian	8	1711/1141	0%	0.57	Fixed	1.42 [0.87, 2.33]	0.16
	African	1	90/55	—	—	—	0.26 [0.10, 0.66]	0.005
		13	2869/2593	63%	0.001	Random	0.72 [0.51, 1.01]	0.05
		4	767/780	8%	0.35	Fixed	1.18 [0.82, 1.72]	0.37
Allele comparison (A versus G)	AITD	18	3736/3473	72%	<0.001	Random	0.96 [0.81, 1.13]	0.63
	HT	8	1009/1089	58%	0.02	Random	1.08 [0.81, 1.44]	0.60
	GD	12	2627/2769	80%	<0.001	Random	0.97 [0.77, 1.21]	0.76
	European	8	1835/2177	66%	0.005	Random	0.82 [0.69, 0.98]	0.02
	Asian	8	1711/1141	58%	0.02	Random	1.41 [1.05, 1.90]	0.02
	African	2	190/155	72%	0.06	Random	0.64 [0.35, 1.15]	0.14
		13	2969/2693	70%	<0.001	Random	0.89 [0.75, 1.06]	0.21
		4	767/780	79%	0.002	Random	1.44 [0.78, 2.65]	0.24

P_H: value of heterogeneity test; P_Z: value of Z test.