International Journal of Endocrinology

Research Article

Are Psychosocial Consequences of Obesity and Hyperandrogenism Present in Adolescent Girls with Polycystic Ovary Syndrome?

Table 2

Clinical and hormonal characteristics of adolescent girls with polycystic ovary syndrome (PCOS) (G3 and G4) and control groups of healthy girls (G1 and G2).


	G1 ()	G2 ()	G3 ()	G4 ()

Chronological age (years)	16.8 (15.8–17.3)	16.5 (14.3–17.0)	17.1 (16.2–17.5)	16.7 (15.6–17.1)
Gynaecological age (months)	45.0 (38.5–56.5)	58.5 (29.5–73.5)	50.0 (44.0–60.0)	47.0 (31.0–64.0)
Cycle duration (days)	28.0 (26.0–37.5)	28.5 (28.0–33.0)	60.0 (30.5–78.0)^1,2	45.0 (30.0–180.0)^3,4
BMI z-score	0.1 ± 0.9	2.2 ± 0.5⁵	0.6 ± 0.8⁶	2.3 ± 0.6^7,8
Ferriman-Gallwey score	2.0 (0.0–1.0)	3.0 (0.0–6.5)	8.0 (3.0–11.0)^9,10	10.0 (7.0–12.5)^11,12
Ferriman-Gallwey score ≥ 8 (number (%))	0 (0%)	0 (0%)	17 (57%)	24 (75%)
Menstrual disturbances (number (%))	2.0 (8.3%)	0 (0%)	20 (66.7%)	21 (65.6%)
Testosterone (ng/dl)	50.5 ± 23.8	48.1 ± 26.6	59.6 ± 22.5	63.6 ± 30.1¹³
Androstenedione (ng/ml)	3.6 ± 1.5	2.8 ± 1.3	4.4 ± 1.9¹⁴	4.1 ± 1.5¹⁵
DHEAS (μg/dl)	297.6 ± 79.7	261.0 ± 96.9	289.8 ± 90.6	285.9 ± 136.3
17OH progesterone (ng/ml)	1.9 (1.4–2.1)	1.5 (1.1–2.2)	1.6 (1.3–2.7)	1.5 (1.2–2.2)
Glucose (mg/dl)	84.4 ± 7.8	86.7 ± 7.4	86.0 ± 6.6	86.3 ± 9.4
Insulin (μIU/ml)	9.4 (5.8–12.7)	18.8 (13.4–23.4)^16,17	8.7 (5.7–11.8)	16.3 (10.7–20.3)^18,19
HOMA-IR	1.9 (1.1–2.7)	4.1 (2.6–4.8)^20,21	1.8 (1.1–2.4)	3.6 (2.4–4.2)^22,23

Note: values are mean ± standard deviation or median (interquartile range). G1: 24 lean girls (BMI < 97th centile) without clinical features of hyperandrogenism; G2: 18 obese girls (BMI > 97th centile) without clinical symptoms of androgen excess; G3: 30 girls with normal body weight (BMI < 97th centile) but with clinical features of hyperandrogenism; and G4: 32 obese girls (BMI > 97th centile) with menstrual disturbances and/or hirsutism. HOMA-IR: homeostatic model of insulin resistance. ¹G1 versus G3: . ²G2 versus G3: . ³G1 versus G4: . ⁴G2 versus G4: . ⁵G1 versus G2: . ⁶G2 versus G3: . ⁷G1 versus G4: . ⁸G2 versus G4: . ⁹G1 versus G3: . ¹⁰G2 versus G3: . ¹¹G1 versus G4: . ¹²G2 versus G4: . ¹³G1 versus G4: . ¹⁴G1 versus G3: . ¹⁵G1 versus G4: . ¹⁶G1 versus G2: . ¹⁷G2 versus G3: . ¹⁸G1 versus G4: . ¹⁹G3 versus G4: . ²⁰G1 versus G2: . ²¹G2 versus G3: . ²²G1 versus G4: . ²³G3 versus G4: .