Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid?

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left"></td><td class="align_center">NM</td><td class="align_center">Product (bp)</td><td class="align_center">Forward (5<svg height="11.4859pt" id="M1" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg> to 3<svg height="11.4859pt" id="M2" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>)</td><td class="align_center">Reverse (5<svg height="11.4859pt" id="M3" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg> to 3<svg height="11.4859pt" id="M4" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z"></path></g></svg>)</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Human NIS</td><td class="align_center">000453.2</td><td class="align_center">180</td><td class="align_center">GTCCTTCAGGGCTCCTTCACC</td><td class="align_center">CTGCTCGCTGGGTGGGTACA</td></tr><tr><td class="align_left">Human TPO</td><td class="align_center">000547.5</td><td class="align_center">241</td><td class="align_center">CTGTCTGTCACGCTGGTTATGG</td><td class="align_center">TCACTCCGCTTGTTGGCTCA</td></tr><tr><td class="align_left">Human Tg</td><td class="align_center">003235.4</td><td class="align_center">203</td><td class="align_center">TTCTTTGAATGTGAACGACGGTG</td><td class="align_center">AAGGGATAGGTGTGGACTTCAATGT</td></tr><tr><td class="align_left">Human BiP</td><td class="align_center">005347.4</td><td class="align_center">150</td><td class="align_center">GCCTGTATTTCTAGACCTGCC</td><td class="align_center">TTCATCTTGCCAGCCAGTTG</td></tr><tr><td class="align_left">Human <i>β</i>-actin</td><td class="align_center">001101</td><td class="align_center">104</td><td class="align_center">ACAGAGCCTCGCCTTTGCCG</td><td class="align_center">ACATGCCGGAGCCGTTGTCG</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>NIS: sodium iodide symporter; TPO: thyroperoxidase; Tg: thyroglobulin; BiP: binding immunoglobulin protein.<br/></div></td></tr></table>

<div>Primers for quantitative real-time PCR in the study.</div>

International Journal of Endocrinology

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Table 1

Table 1: Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid? 

Table 1 | Palmitic Acid Downregulates Thyroglobulin (Tg), Sodium Iodide Symporter (NIS), and Thyroperoxidase (TPO) in Human Primary Thyrocytes: A Potential Mechanism by Which Lipotoxicity Affects Thyroid? 