Uncoupling Protein 2 and Peroxisome Proliferator-Activated Receptor γ Gene Polymorphisms in Association with Diabetes Susceptibility in Chinese Han Population with Variant Glucose Tolerance
Table 10
Association of genotype with insulin secretion function and blood glucose in PPARγ.
Genotype
HbA1c%
FPG (mmol/l)
Glu30 (mmol/l)
Glu60 (mmol/l)
Glu120 (mmol/l)
Ins0 (μIU/ml)
Ins30 (μIU/ml)
Ins60 (μIU/ml)
Ins120 (μIU/ml)
HOMA-IR
HOMA-β
DI30
DI120
rs2920503
CC
6.06 ± 0.08
6.84 ± 0.16
11.34 ± 0.23
11.16 ± 0.32
9.17 ± 0.33
11.59 ± 0.57
73.21 ± 3.49
74.50 ± 3.44
50.88 ± 2.74
3.69 ± 0.33
85.26 ± 3.25
423.09 ± 18.98
577.78 ± 37.56
CT
6.10 ± 0.08
6.87 ± 0.16
11.32 ± 0.25
11.55 ± 0.33
9.69 ± 0.35
13.10 ± 0.86
72.05 ± 3.91
82.18 ± 3.95
53.29 ± 6.52
4.15 ± 0.32
92.27 ± 5.27
387.24 ± 19.31
527.33 ± 20.78
TT
5.59 ± 0.11
5.98 ± 0.12
9.82 ± 0.29
9.33 ± 0.44
7.72 ± 0.35
12.05 ± 0.92
78.26 ± 8.06
78.79 ± 6.95
62.76 ± 3.49
3.31 ± 0.29
101.01 ± 6.49
460.64 ± 35.70
592.80 ± 31.89
value
0.019
0.039
0.012
0.01
0.034
0.295
0.77
0.332
0.024
0.405
0.186
0.178
0.434
rs73813168
AA
6.02 ± 0.06
6.77 ± 0.12
11.16 ± 0.18
11.14 ± 0.24
9.32 ± 0.25
11.90 ± 0.41
71.68 ± 2.77
78.64 ± 2.76
57.65 ± 2.39
3.67 ± 0.17
87.72 ± 2.87
402.67 ± 13.84
556.93 ± 24.92
GA
6.04 ± 0.11
6.78 ± 0.23
11.21 ± 0.32
11.13 ± 0.46
8.87 ± 0.46
12.14 ± 1.04
75.88 ± 5.27
76.82 ± 5.22
52.35 ± 4.13
3.99 ± 0.63
89.11 ± 5.46
439.29 ± 29.79
570.00 ± 31.05
GG
5.85 ± 0.12
5.99 ± 0.19
11.09 ± 0.80
10.54 ± 1.91
6.21 ± 1.12
12.59 ± 3.34
99.09 ± 51.54
73.55 ± 20.46
43.04 ± 15.77
3.35 ± 0.86
102.59 ± 30.85
414.77 ± 154.51
513.87 ± 66.05
value
0.947
0.814
0.99
0.97
0.336
0.96
0.506
0.939
0.479
0.777
0.864
0.477
0.946
rs79310821
GA
6.16 ± 0.08
7.08 ± 0.18
11.59 ± 0.24
11.76 ± 0.33
9.92 ± 0.35
12.81 ± 0.87
68.22 ± 3.24
76.64 ± 3.47
56.29 ± 3.03
3.92 ± 0.36
83.64 ± 3.79
412.36 ± 20.56
522.64 ± 21.28
GG
5.91 ± 0.08
6.52 ± 0.13
10.80 ± 0.22
10.68 ± 0.31
8.71 ± 0.31
12.14 ± 0.48
76.31 ± 3.96
78.00 ± 3.63
56.77 ± 3.09
3.80 ± 0.28
91.79 ± 4.26
403.67 ± 16.44
586.01 ± 36.88
AA
5.89 ± 0.11
6.39 ± 0.17
10.67 ± 0.37
10.13 ± 0.51
8.30 ± 0.52
10.14 ± 0.62
78.61 ± 8.39
80.96 ± 8.19
56.84 ± 6.70
3.50 ± 0.33
105.43 ± 8.54
442.89 ± 46.25
583.89 ± 43.95
value
0.055
0.015
0.029
0.012
0.009
0.192
0.21
0.856
0.993
0.855
0.069
0.695
0.301
rs73021485
GT
6.14 ± 0.08
7.06 ± 0.18
11.59 ± 0.24
11.74 ± 0.32
9.86 ± 0.34
12.32 ± 0.82
68.11 ± 3.22
76.83 ± 3.47
56.48 ± 3.03
4.14 ± 0.40
82.09 ± 3.90
373.32 ± 17.21
509.27 ± 19.15
GG
5.91 ± 0.08
6.51 ± 0.13
10.80 ± 0.22
10.67 ± 0.31
8.67 ± 0.31
12.17 ± 0.48
76.73 ± 3.97
78.64 ± 3.66
56.42 ± 3.09
3.56 ± 0.17
96.67 ± 4.06
438.29 ± 20.28
564.71 ± 19.91
TT
5.97 ± 0.12
6.51 ± 0.19
10.74 ± 0.39
10.30 ± 0.55
8.59 ± 0.57
11.87 ± 1.25
78.18 ± 8.14
80.13 ± 7.86
56.92 ± 6.44
3.52 ± 0.48
91.36 ± 9.05
460.55 ± 37.27
724.86 ± 133.17I
value
0.112
0.028
0.031
0.019
0.021
0.949
0.186
0.89
0.997
0.363
0.041
0.018
0.004
rs2920502
GC
6.20 ± 0.10
7.11 ± 0.19
11.58 ± 0.26
11.67 ± 0.35
8.98 ± 0.28
11.75 ± 0.64
71.26 ± 3.88
73.99 ± 3.59
54.91 ± 5.56
3.56 ± 0.17
84.54 ± 4.31
436.29 ± 20.24
561.96 ± 19.83
CC
6.02 ± 0.06
7.15 ± 0.11
11.85 ± 0.19
11.76 ± 0.27
9.76 ± 0.38
12.55 ± 0.73
73.30 ± 3.47
70.05 ± 3.57
50.38 ± 2.98
4.33 ± 0.42
96.17 ± 4.05
373.56 ± 17.36
507.65 ± 19.37
GG
5.74 ± 0.11
6.25 ± 0.24
10.72 ± 0.46
10.43 ± 0.64
7.82 ± 0.52
12.68 ± 1.00
80.64 ± 7.31
85.24 ± 7.56
62.44 ± 3.16
2.81 ± 0.19
83.97 ± 6.40
470.32 ± 37.73
743.78 ± 136.80
value
0.009
0.01
0.049
0.068
0.032
0.663
0.579
0.015
0.019
0.041
0.104
0.015
0.002
rs17029007
GG
6.01 ± 0.06
6.77 ± 0.12
11.14 ± 0.18
11.12 ± 0.24
9.30 ± 0.25
12.18 ± 0.50
71.74 ± 2.75
78.71 ± 2.74
57.73 ± 2.40
3.76 ± 0.19
89.10 ± 3.15
402.92 ± 13.76
557.25 ± 24.78
GA
6.00 ± 0.11
6.76 ± 0.24
11.23 ± 0.33
11.16 ± 0.48
8.98 ± 0.49
12.35 ± 1.09
75.56 ± 5.32
76.13 ± 5.39
52.52 ± 4.26
4.05 ± 0.65
90.98 ± 5.74
437.31 ± 30.27
563.96 ± 31.32
AA
6.26 ± 0.50
6.01 ± 0.16
10.68 ± 0.62
9.78 ± 1.21
6.35 ± 0.79
10.79 ± 1.81
111.10 ± 30.97
79.93 ± 13.81
49.28 ± 10.87
2.87 ± 0.47
89.40 ± 17.08
514.60 ± 108.50
642.35 ± 83.52
value
0.837
0.684
0.903
0.741
0.231
0.92
0.138
0.904
0.532
0.725
0.96
0.319
0.873
rs3856806
CC
5.96 ± 0.06
6.57 ± 0.11
10.92 ± 0.18
10.78 ± 0.25
8.93 ± 0.26
11.87 ± 0.41
75.61 ± 3.14
77.37 ± 3.07
56.12 ± 2.58
3.51 ± 0.14
91.40 ± 3.05
432.97 ± 16.46
582.14 ± 29.37
TC
6.12 ± 0.10
7.11 ± 0.22
11.58 ± 0.29
11.68 ± 0.39
9.69 ± 0.40
12.75 ± 1.08
69.35 ± 4.21
78.76 ± 4.16
56.36 ± 3.54
4.33 ± 0.53
86.40 ± 5.67
377.68 ± 20.08
518.92 ± 22.77
TT
6.08 ± 0.21
7.88 ± 0.47
11.33 ± 0.82
11.60 ± 1.24
9.27 ± 1.42
12.59 ± 2.01
62.15 ± 8.81
77.54 ± 11.07
58.24 ± 12.15
4.36 ± 1.22
82.71 ± 11.35
358.63 ± 57.56
506.31 ± 62.29
value
0.326
0.047
0.127
0.121
0.257
0.65
0.338
0.964
0.981
0.155
0.619
0.085
0.302
. DI30 (early-phase disposition index of insulin secretion) = [InsAUC30/GluAUC30] × ISIM, DI120 (total-phase disposition of insulin secretion) = [InsAUC120/GluAUC120] × ISIM.
