Elevated Serum IL-17 Expression at Cessation Associated with Graves’ Disease Relapse

Table 3

Risk factors for GD relapse by univariate and multiple Cox proportional hazard analysis.

Parameters	Univariate		Multivariate
	HR (95% CI)	value	HR (95% CI)	value
Age at diagnosis	2.07 (1.11–3.55)	0.021	0.77 (0.34–1.55)	0.44
Graves’ ophthalmopathy	1.17 (1.03–1.29)	0.014	1.01 (0.97–1.04)	0.52
Time to normalization of TSH	2.11(0.45–6.12)	0.27
Time to normalization of fT4	1.17(0.31–4.68)	0.75
TSH at cessation	0.98(0.94–1.04)	0.54
TRAb at cessation	3.12 (1.06–8.78)	0.042	1.11 (0.89–1.33)	0.23
IL-4 at cessation	1.07(0.29–3.45)	0.13
IL-17 at cessation	1.93 (1.16–3.11)	0.011	3.04 (1.14–7.67)	0.021

GD: Graves’ disease; TSH: thyrotropin-stimulating hormone; fT4: free thyroxine; TRAb: thyrotropin receptor antibody; IL-4: interleukin-4; IL-17: interleukin-17; CI: confidence interval; HR: hazard ratio. .