Review Article

Role of the Wnt/β-Catenin Pathway in Renal Osteodystrophy

Figure 4

Mechanisms of action of common Wnt inhibitors. Sclerostin (light green) and Dkk1 (light pink) both prevent Wnt/β-catenin pathway activation by binding to Lrp5/6, which prevents its interaction with Frizzled (Fz). The primary mechanism of action of SFRPs (blue) is to bind to Wnt molecules thus preventing its interaction with its receptor and further activate the Wnt/β-catenin pathway.