Leptin Modifies the Rat Heart Performance Associated with Mitochondrial Dysfunction Independently of Its Prohypertrophic Effects

Table 1

Summary of respiratory control (RC) measured by conventional oximetry with a Clark-type electrode in isolated mitochondria. Oxygen consumption was analyzed with substrates for complex I (glutamate/malate) and complex II (succinate + rotenone) by measuring the slopes of state 4 and state 3, as shown in Figure 2. Values represent ; ().

Perfusion time (hr)	1		2		3		4
	Ctrl	Lep	Ctrl	Lep	Ctrl	Lep	Ctrl	Lep
Glutamate-malate: (complex I)	2.07 ± 0.3	1.18 ± 0.1	2.26 ± 0.8	1.27 ± 0.3	1.80 ± 0.4	1.34 ± 0.1	2.96 ± 0.9	1.14 ± 0.1
Succinate: (complex II)	2.94 ± 1.1	1.28 ± 0.2	2.67 ± 0.8	1.19 ± 0.2	2.95 ± 0.5	1.15 ± 0.08	2.17 ± 0.7	1.18 ± 0.1