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International Journal of Endocrinology
Volume 2018, Article ID 6484839, 11 pages
https://doi.org/10.1155/2018/6484839
Review Article

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

1Hunan University of Chinese Medicine, Changsha 410208, China
2Jiangxi Provincial People’s Hospital, Nanchang 330006, China

Correspondence should be addressed to Xiao-he Wu; moc.361@yzykhxw and Hui-yong Huang; moc.621@86yhgnauh

Received 15 March 2018; Accepted 26 July 2018; Published 16 September 2018

Academic Editor: Alberto Ferlin

Copyright © 2018 Shi-ying Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Q. Shen and J. D. Pierce, “Supplementation of coenzyme Q10 among patients with type 2 diabetes mellitus,” Healthcare, vol. 3, no. 2, pp. 296–309, 2015. View at Publisher · View at Google Scholar
  2. World Health Organization, Global Status Report Noncommunicable Diseases 2016, World Health Organization, Geneva (Switzerland), 2016.
  3. Centers for Disease Control and Prevention, National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014, USA Department of Health and Human Services, Atlanta, GA, USA, 2014.
  4. A. Rawshani, A. Rawshani, S. Franzén et al., “Mortality and cardiovascular disease in type 1 and type 2 diabetes,” New England Journal of Medicine, vol. 376, no. 15, pp. 1407–1418, 2017. View at Publisher · View at Google Scholar · View at Scopus
  5. A. G. Tabák, C. Herder, W. Rathmann, E. J. Brunner, and M. Kivimäki, “Prediabetes: a high-risk state for diabetes development,” The Lancet, vol. 379, no. 9833, pp. 2279–2290, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. International Diabetes Federation, IDF Diabetes Atlas, Brussels, Belgium, International Diabetes Federation, 2013, http://www.idf.org/diabetesatlas.
  7. American Diabetes Association, “15. Diabetes advocacy: standards of medical care in diabetes—2018,” Diabetes Care, vol. 41, Supplement 1, pp. S152–S153, 2018. View at Publisher · View at Google Scholar · View at Scopus
  8. R. C. Ruhe and R. B. McDonald, “Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes,” Journal of the American College of Nutrition, vol. 20, Supplement 5, pp. 363S–369S, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. I. S. Al-Gadi, R. H. Haas, M. J. Falk, A. Goldstein, and S. E. McCormack, “Endocrine disorders in primary mitochondrial disease,” Journal of the Endocrine Society, vol. 2, no. 4, pp. 361–373, 2018. View at Publisher · View at Google Scholar
  10. S. Yagihashi, W. Inaba, and H. Mizukami, “Dynamic pathology of islet endocrine cells in type 2 diabetes: β-cell growth, death, regeneration and their clinical implications,” Journal of Diabetes Investigation, vol. 7, no. 2, pp. 155–165, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. D. W. Lamson and S. M. Plaza, “Mitochondrial factors in the pathogenesis of diabetes: a hypothesis for treatment,” Alternative Medicine Review, vol. 7, no. 2, pp. 94–111, 2002. View at Google Scholar
  12. Y. Meng, A. Eirin, X. Y. Zhu et al., “Obesity-induced mitochondrial dysfunction in porcine adipose tissue-derived mesenchymal stem cells,” Journal of Cellular Physiology, vol. 233, no. 8, pp. 5926–5936, 2018. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Brøns, S. Jacobsen, N. Hiscock et al., “Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects,” American Journal of Physiology-Endocrinology and Metabolism, vol. 302, no. 1, pp. E43–E51, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. I. P. Chatziralli, G. Theodossiadis, P. Dimitriadis et al., “The effect of vitamin E on oxidative stress indicated by serum malondialdehyde in insulin-dependent type 2 diabetes mellitus patients with retinopathy,” The Open Ophthalmology Journal, vol. 11, no. 1, pp. 51–58, 2017. View at Publisher · View at Google Scholar · View at Scopus
  15. L. M. Román-Pintos, G. Villegas-Rivera, A. D. Rodríguez-Carrizalez, A. G. Miranda-Díaz, and E. G. Cardona-Muñoz, “Diabetic polyneuropathy in type 2 diabetes mellitus: inflammation, oxidative stress, and mitochondrial function,” Journal of Diabetes Research, vol. 2016, Article ID 3425617, 16 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. G. Hasegawa, Y. Yamamoto, J. G. Zhi et al., “Daily profile of plasma %CoQ10 level, a biomarker of oxidative stress, in patients with diabetes manifesting postprandial hyperglycaemia,” Acta Diabetologica, vol. 42, no. 4, pp. 179–181, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. I. S. Daehn, “Glomerular endothelial cell stress and cross-talk with podocytes in early diabetic kidney disease,” Frontiers in Medicine, vol. 5, p. 76, 2018. View at Publisher · View at Google Scholar
  18. M. Mezawa, M. Takemoto, S. Onishi et al., “The reduced form of coenzyme Q10 improves glycemic control in patients with type 2 diabetes: an open label pilot study,” BioFactors, vol. 38, no. 6, pp. 416–421, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. J. G. Eriksson, T. J. Forsen, S. A. Mortensen, and M. Rohde, “The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus,” BioFactors, vol. 9, no. 2-4, pp. 315–318, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. M. A. Alam and M. M. Rahman, “Mitochondrial dysfunction in obesity: potential benefit and mechanism of co-enzyme Q10 supplementation in metabolic syndrome,” Journal of Diabetes & Metabolic Disorders, vol. 13, no. 1, p. 60, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. N. Suksomboon, N. Poolsup, and N. Juanak, “Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis,” Journal of Clinical Pharmacy and Therapeutics, vol. 40, no. 4, pp. 413–418, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Moradi, F. Haghighatdoost, A. Feizi, B. Larijani, and L. Azadbakht, “Effect of coenzyme Q10 supplementation on diabetes biomarkers: a systematic review and meta-analysis of randomized controlled clinical trials,” Archives of Iranian Medicine, vol. 19, no. 8, pp. 588–596, 2016. View at Google Scholar
  23. J. J. Deeks, J. P. Higgins, and D. G. Altman, “Chapter 16: special topics in statistics,” in Cochrane Handbook for Systematic Reviews of Interventions, J. P. Higgins and S. Green, Eds., The Cochrane Collaboration, UK, 2011. View at Google Scholar
  24. J. J. Deeks, J. P. Higgins, and D. G. Altman, “Chapter 8: assessing risk of bias in included studies,” in Cochrane Handbook or Systematic Reviews of Interventions Version 5.1.0, J. P. Higgins and S. Green, Eds., The Cochrane Collaboration, UK, 2011. View at Google Scholar
  25. J. J. Deeks, J. P. Higgins, and D. G. Altman, “Chapter 9: analyzing data and undertaking meta-analyses,” in Cochrane Handbook for Systematic Reviews of Interventions, J. P. Higgins and S. Green, Eds., The Cochrane Collaboration, UK, 2011. View at Google Scholar
  26. D. A. Playford, G. F. Watts, K. D. Croft, and V. Burke, “Combined effect of coenzyme Q10 and fenofibrate on forearm microcirculatory function in type 2 diabetes,” Atherosclerosis, vol. 168, no. 1, pp. 169–179, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. G. T. Chew, G. F. Watts, T. M. E. Davis et al., “Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction,” Diabetes Care, vol. 31, no. 8, pp. 1502–1509, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. J. M. Hodgson, G. F. Watts, D. A. Playford, V. Burke, and K. D. Croft, “Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes,” European Journal of Clinical Nutrition, vol. 56, no. 11, pp. 1137–1142, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Akbari Fakhrabadi, A. Zeinali Ghotrom, H. Mozaffari-Khosravi, H. Hadi Nodoushan, and A. Nadjarzadeh, “Effect of coenzyme Q10 on oxidative stress, glycemic control and inflammation in diabetic neuropathy: a double blind randomized clinical trial,” International Journal for Vitamin and Nutrition Research, vol. 84, no. 5-6, pp. 252–260, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Gholami, M. R. Rezvanfar, M. Delavar, M. Abdollahi, and A. Khosrowbeygi, “Effects of coenzyme Q10 supplementation on serum values of gamma-glutamyl transferase, pseudocholinesterase, bilirubin, ferritin, and high-sensitivity C-reactive protein in women with type 2 diabetes,” Experimental and Clinical Endocrinology & Diabetes, 2018. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Zahedi, S. Eghtesadi, S. Seifirad et al., “Effects of CoQ10 supplementation on lipid profiles and glycemic control in patients with type 2 diabetes: a randomized, double blind, placebo-controlled trial,” Journal of Diabetes and Metabolic Disorders, vol. 13, no. 1, p. 81, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. N. K. Mohammed-Jawad and M. Al- Sabbagh, “Role of L-carnitine and coenzyme Q10 as adjuvant therapy in patients with type 2 diabetes mellitus,” American Journal of Pharmacological Sciences, vol. 2, no. 5, pp. 82–86, 2014. View at Publisher · View at Google Scholar
  33. M. Moazen, Z. Mazloom, A. Ahmadi, M. H. Dabbaghmanesh, and S. Roosta, “Effect of coenzyme Q10 on glycaemic control, oxidative stress and adiponectin in type 2 diabetes,” The Journal of the Pakistan Medical Association, vol. 65, no. 4, pp. 404–408, 2015. View at Google Scholar
  34. M. Hosseinzadeh-Attar, R. Kolahdouz Mohammadi, M. Eshraghian et al., “Reduction in asymmetric dimethylarginine plasma levels by coenzyme Q10 supplementation in patients with type 2 diabetes mellitus,” Minerva Endocrinologica, vol. 40, no. 4, pp. 259–266, 2015. View at Google Scholar
  35. S. C. Lim, R. Lekshminarayanan, S. K. Goh et al., “The effect of coenzyme Q10 on microcirculatory endothelial function of subjects with type 2 diabetes mellitus,” Atherosclerosis, vol. 196, no. 2, pp. 966–969, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Mehrdadi, R. Kolahdouz Mohammadi, E. Alipoor, M. R. Eshraghian, A. Esteghamati, and M. J. Hosseinzadeh-Attar, “The effect of coenzyme Q10 supplementation on circulating levels of novel adipokine adipolin/CTRP12 in overweight and obese patients with type 2 diabetes,” Experimental and Clinical Endocrinology & Diabetes, vol. 125, no. 3, pp. 156–162, 2017. View at Publisher · View at Google Scholar · View at Scopus
  37. R. Kolahdouz Mohammadi, M. J. Hosseinzadeh-Attar, M. R. Eshraghian, M. Nakhjavani, E. Khorami, and A. Esteghamati, “The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients,” Minerva Gastroenterologica e Dietologica, vol. 59, no. 2, pp. 231–236, 2013. View at Google Scholar
  38. S. Yamashita and Y. Yamamoto, “Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress,” Analytical Biochemistry, vol. 250, no. 1, pp. 66–73, 1997. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Yubero, R. Montero, M. A. Martín et al., “Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders,” Mitochondrion, vol. 30, pp. 51–58, 2016. View at Publisher · View at Google Scholar · View at Scopus
  40. M. M. Amin, G. F. Asaad, R. M. Abdel Salam, H. S. El-Abhar, and M. S. Arbid, “Novel CoQ10 antidiabetic mechanisms underlie its positive effect: modulation of insulin and adiponectine receptors, tyrosine kinase, PI3K, glucose transporters, sRAGE and visfatin in insulin resistant/diabetic rats,” PLoS One, vol. 9, no. 2, article e89169, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. Loke, D. Price, and A. Herxheimer, “Chapter 14: adverse effects,” in Cochrane Handbook for Systematic Reviews of Interventions. Chapter 14, H. JPT and S. Green, Eds., John Wiley & Sons, Chichester, UK, 2011. View at Google Scholar
  42. J. P. A. Ioannidis, S. J. W. Evans, P. C. Gøtzsche et al., “Better reporting of harms in randomized trials: an extension of the CONSORT statement,” Annals of Internal Medicine, vol. 141, no. 10, pp. 781–788, 2004. View at Publisher · View at Google Scholar · View at Scopus