Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Table 2

The characteristics of the included studies.

Study	Sample size		Intervention		Relevant outcomes	Mean age (years)		Duration
	Trial group	Control group	Trial group	Control group		Trial group	Control group
Hodgson et al. [28]	38	36	Coenzyme Q10 200 mg or coenzyme Q10 200 mg + fenofibrate 200 mg	Placebo or fenofibrate 200 mg	HbA1c	52 ± 6.41	54.4 ± 9.88	12 weeks
Playford et al. [26]	38	35	Coenzyme Q10 200 mg or coenzyme Q10 200 mg + fenofibrate 200 mg	Placebo or fenofibrate 200 mg	HbA1c, TG, TC, HDL-C, LDL-C	52.7 ± 9.80	54.1 ± 13.7	12 weeks
Moazen et al. [33]	26	26	Coenzyme Q10 200 mg	Microcrystalline cellulose (placebo)	Fasting blood glucose, HbA1c, adiponectin	50.67 ± 7.01	52.79 ± 7.66	8 weeks
Akbari Fakhrabadi et al. [29]	32	30	Coenzyme Q10 200 mg	Microcrystalline cellulose (placebo)	Fasting blood glucose, fasting insulin, HbA1c, HOMA-IR, TC, HDL-C, LDL-C	56.7 ± 6.4	54.8 ± 6.7	12 weeks
Gholami et al. [30]	35	35	Coenzyme Q10 100 mg	Cellulose acetate 100 mg	Fasting blood glucose, fasting insulin, HbA1c, HOMA-IR, TC, TG, HDL-C, LDL-C	52.97 ± 1.04	53.68 ± 1.14	12 weeks
Zahedi et al. [31]	20	20	Coenzyme Q10 150 mg	Maize starch 150 mg	Fasting blood glucose, fasting insulin, HbA1c, HOMA-IR, TC, TG, HDL-C, LDL-C	53.5 ± 9.7	58.8 ± 9.6	12 weeks
Chew et al. [27]	36	33	Coenzyme Q10 200 mg or coenzyme Q10 200 mg + fenofibrate 160 mg	Placebo or fenofibrate 160 mg	Fasting blood glucose, HbA1c, TC, TG, HDL-C, LDL-C	62.22 ± 7.41	63.57 ± 8.09	24 weeks
Hosseinzadeh-Attar et al. [34]	31	33	Coenzyme Q10 200 mg	Maize starch 200 mg	Fasting blood glucose, HbA1c, TC, TG, HDL-C, LDL-C	45.2 ± 7.6	47.1 ± 8.3	12 weeks
Mohammed-Jawad et al. [32]	19	19	Coenzyme Q10 200 mg + antidiabetic drugs	Antidiabetic drugs	Fasting blood glucose, HbA1c, TC, HDL-C, LDL-C	49.37 ± 6.65	51.63 ± 8.13	8 weeks
Eriksson et al. [19]	12	11	Coenzyme Q10 200 mg	Placebo 200 mg	Fasting blood glucose, HbA1c, TC, TG, HDL-C	65 ± 17.32	64 ± 23.22	24 weeks
Lim et al. [35]	40	40	Coenzyme Q10 200 mg	Placebo 200 mg	Fasting blood glucose, HbA1c	54 ± 9	53 ± 9	12 weeks
Mehrdadi et al. [36]	26	30	Coenzyme Q10 200 mg	Placebo 200 mg	Fasting blood glucose, fasting insulin, HbA1c, adipolin, HOMA-IR	46 ± 7	48 ± 8	12 weeks
Kolahdouz Mohammadi et al. [37]	31	33	Coenzyme Q10 200 mg	Placebo 200 mg	Fasting blood glucose, HbA1c, TG, TC, HDL-C, LDL-C	45.23 ± 7.64	47.18 ± 8.31	12 weeks