Table 2: The characteristics of the included studies.

StudySample sizeInterventionRelevant outcomesMean age (years)Duration
Trial groupControl groupTrial groupControl groupTrial groupControl group

Hodgson et al. [28]3836Coenzyme Q10 200 mg or coenzyme Q10 200 mg + fenofibrate 200 mgPlacebo or fenofibrate 200 mgHbA1c52 ± 6.4154.4 ± 9.8812 weeks
Playford et al. [26]3835Coenzyme Q10 200 mg or coenzyme Q10 200 mg + fenofibrate 200 mgPlacebo or fenofibrate 200 mgHbA1c, TG, TC, HDL-C, LDL-C52.7 ± 9.8054.1 ± 13.712 weeks
Moazen et al. [33]2626Coenzyme Q10 200 mgMicrocrystalline cellulose (placebo)Fasting blood glucose, HbA1c, adiponectin50.67 ± 7.0152.79 ± 7.668 weeks
Akbari Fakhrabadi et al. [29]3230Coenzyme Q10 200 mgMicrocrystalline cellulose (placebo)Fasting blood glucose, fasting insulin, HbA1c, HOMA-IR, TC, HDL-C, LDL-C56.7 ± 6.454.8 ± 6.712 weeks
Gholami et al. [30]3535Coenzyme Q10 100 mgCellulose acetate 100 mgFasting blood glucose, fasting insulin, HbA1c, HOMA-IR, TC, TG, HDL-C, LDL-C52.97 ± 1.0453.68 ± 1.1412 weeks
Zahedi et al. [31]2020Coenzyme Q10 150 mgMaize starch 150 mgFasting blood glucose, fasting insulin, HbA1c, HOMA-IR, TC, TG, HDL-C, LDL-C53.5 ± 9.758.8 ± 9.612 weeks
Chew et al. [27]3633Coenzyme Q10 200 mg or coenzyme Q10 200 mg + fenofibrate 160 mgPlacebo or fenofibrate 160 mgFasting blood glucose, HbA1c, TC, TG, HDL-C, LDL-C62.22 ± 7.4163.57 ± 8.0924 weeks
Hosseinzadeh-Attar et al. [34]3133Coenzyme Q10 200 mgMaize starch 200 mgFasting blood glucose, HbA1c, TC, TG, HDL-C, LDL-C45.2 ± 7.647.1 ± 8.312 weeks
Mohammed-Jawad et al. [32]1919Coenzyme Q10 200 mg + antidiabetic drugsAntidiabetic drugsFasting blood glucose, HbA1c, TC, HDL-C, LDL-C49.37 ± 6.6551.63 ± 8.138 weeks
Eriksson et al. [19]1211Coenzyme Q10 200 mgPlacebo 200 mgFasting blood glucose, HbA1c, TC, TG, HDL-C65 ± 17.3264 ± 23.2224 weeks
Lim et al. [35]4040Coenzyme Q10 200 mgPlacebo 200 mgFasting blood glucose, HbA1c54 ± 953 ± 912 weeks
Mehrdadi et al. [36]2630Coenzyme Q10 200 mgPlacebo 200 mgFasting blood glucose, fasting insulin, HbA1c, adipolin, HOMA-IR46 ± 748 ± 812 weeks
Kolahdouz Mohammadi et al. [37]3133Coenzyme Q10 200 mgPlacebo 200 mgFasting blood glucose, HbA1c, TG, TC, HDL-C, LDL-C45.23 ± 7.6447.18 ± 8.3112 weeks