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International Journal of Endocrinology
Volume 2018, Article ID 6546832, 8 pages
Research Article

GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly

Xia Wu,1,2,3 Lu Gao,1,2,3 Xiaopeng Guo,1,2,3 Qiang Wang,1,2,3 Zihao Wang,1,2,3 Wei Lian,1,2,3 Wei Liu,4 Jian Sun,5 and Bing Xing1,2,3

1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
2China Pituitary Disease Registry Center, Chinese Pituitary Adenoma Cooperative Group, Beijing 100730, China
3Key Laboratory of Endocrinology of National Health and Family Planning Commission, Beijing 100730, China
4Department of General Surgery, Peking Union Medical College Hospital, Beijing 100730, China
5Department of Pathology, Peking Union Medical College Hospital, Beijing 100730, China

Correspondence should be addressed to Bing Xing; moc.nuyila@liamegnibgnix

Received 2 July 2017; Revised 12 September 2017; Accepted 12 November 2017; Published 15 January 2018

Academic Editor: Thomas J. Fahey

Copyright © 2018 Xia Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. To determine the prevalence, risk factors, and possible mechanisms of structural and endocrinological changes to the thyroid in acromegaly. Methods. We studied 93 acromegalic patients from PUMCH between January 2013 and December 2013. The demographic and clinical information were recorded. Specimens of pituitary adenomas and thyroid cancer were collected for BRAF mutation assessments. Results. Thyroid morphological abnormalities were found in 72 (77.4%) patients. Three (3.2%) were diagnosed with thyroid cancer. The thyroid gland volume was significantly increased in patients with higher random GH (), higher nadir GH (), and higher IGF-1 level (). Age () was an independent risk factor for thyroid morphological abnormalities in acromegaly. The GH burden was significantly higher in patients with thyroid morphological abnormalities (). The BRAF V600E mutation was detected in the PTCs of the two patients with thyroid cancer. Conclusions. Both benign and malignant thyroid abnormalities are increased in the acromegalic population compared to those in the general population. Age at diagnosis is an independent risk factor for thyroid abnormalities, and GH burden may be a partial contributor. Early diagnosis, early treatment, and monitoring of postoperational endocrine levels are important for acromegalic patients.