GH, IGF-1, and Age Are Important Contributors to Thyroid Abnormalities in Patients with Acromegaly

Table 3

General characteristics of BRAF mutation in DTCs of patients with acromegaly.

Study	Year	Country	Patients with acromegaly	Number of DTCs	Types of DTCs	BRAF mutation rate
Kim et al. [26]	2014	Korea	60	15 (25.0%)	15 PTCs	1/11 (9.1%)
Mian et al. [10]	2014	Italy	113	12 (10.6%)	10 PTCs and 2 FTCs	7/12 (58.3%)
Aydin et al. [25]	2016	Turkey	NA	14	11 PTCs and 3 other types	2/14 (14.3%)
Present study	2017	China	93	3 (3.2%)	2 PTCs and 1 MTC	2/3 (66.7%)

DTC: differentiated thyroid cancer; PTC: papillary thyroid cancer; FTC: follicular thyroid cancer; MTC: medullary thyroid cancer; NA: not available. Other types included two well-differentiated tumors with undetermined follicular neoplasms and one follicular variant and follicular neoplasms.