Research Article

Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population

Table 3

Association between islet β-cell function and rs9840992 genotype in eIF2α.

CC ()TC/TT () value

FBG (mmol/L)5.51 ± 0.555.54 ± 0.570.376
PBG30 (mmol/L)9.35 ± 1.789.54 ± 1.880.201
PBG-2h (mmol/L)7.50 ± 1.677.55 ± 1.760.626
INS0 (mU/L)7.52 (5.98–9.57)7.54 (5.36–10.58)0.656
INS30 (mU/L)49.31 (28.97–70.92)41.23 (26.71–68.05)0.301
INS120 (mU/L)49.86 (30.38–79.61)44.32 (26.42–70.75)0.038
HOMA-β76.00 (57.03–103.79)76.60 (53.72–103.25)0.565
HOMA-IR1.83 (1.41–2.42)1.84 (1.28–2.61)0.440
ΔI30/ΔG3010.82 (6.25–19.35)8.97 (5.35–16.49)0.008
ΔI30/ΔG30/IR5.87 (3.59–10.33)4.88 (2.88–8.24)0.004
ΔI120/ΔG12023.02 (13.47–43.21)19.38 (10.45–36.57)0.017
ΔI120/ΔG120/IR12.11 (8.10–21.93)10.03 (5.84–18.58)0.006
AUCi (mU/Lh)78.60 (54.42–116.29)69.00 (47.51–108.07)0.023
AUCi/IR (mU/Lh)44.08 (32.50–60.36)37.50 (28.50-51.19)3.7 × 10−4

FBG: fasting blood glucose; PBG30: post-OGTT 30 glucose; PBG-2h: post-OGTT 2-hour blood glucose; INS0: fasting insulin levels; INS30: post-OGTT30 insulin levels; INS120: 2-hour post-OGTT insulin levels; HOMA-β: β-cell function; HOMA-IR: homeostasis model assessments of insulin resistance; ΔI30/ΔG30/IR: the ratio of ΔI30/ΔG30 to HOMA-IR; ΔI120/ΔG120/IR: the ratio of ΔI120/ΔG120 to HOMA-IR; AUCi: area under the curve for insulin; AUCi/IR: the ratio of AUCi to HOMA-IR.