Genetic Variability in eIF2α Gene Is Associated with Islet β-Cell Function in the Development of Diabetes in a Chinese Han Population
Table 3
Association between islet β-cell function and rs9840992 genotype in eIF2α.
CC ()
TC/TT ()
value
FBG (mmol/L)
5.51 ± 0.55
5.54 ± 0.57
0.376
PBG30 (mmol/L)
9.35 ± 1.78
9.54 ± 1.88
0.201
PBG-2h (mmol/L)
7.50 ± 1.67
7.55 ± 1.76
0.626
INS0 (mU/L)
7.52 (5.98–9.57)
7.54 (5.36–10.58)
0.656
INS30 (mU/L)
49.31 (28.97–70.92)
41.23 (26.71–68.05)
0.301
INS120 (mU/L)
49.86 (30.38–79.61)
44.32 (26.42–70.75)
0.038
HOMA-β
76.00 (57.03–103.79)
76.60 (53.72–103.25)
0.565
HOMA-IR
1.83 (1.41–2.42)
1.84 (1.28–2.61)
0.440
ΔI30/ΔG30
10.82 (6.25–19.35)
8.97 (5.35–16.49)
0.008
ΔI30/ΔG30/IR
5.87 (3.59–10.33)
4.88 (2.88–8.24)
0.004
ΔI120/ΔG120
23.02 (13.47–43.21)
19.38 (10.45–36.57)
0.017
ΔI120/ΔG120/IR
12.11 (8.10–21.93)
10.03 (5.84–18.58)
0.006
AUCi (mU/Lh)
78.60 (54.42–116.29)
69.00 (47.51–108.07)
0.023
AUCi/IR (mU/Lh)
44.08 (32.50–60.36)
37.50 (28.50-51.19)
3.7 × 10−4
FBG: fasting blood glucose; PBG30: post-OGTT 30 glucose; PBG-2h: post-OGTT 2-hour blood glucose; INS0: fasting insulin levels; INS30: post-OGTT30 insulin levels; INS120: 2-hour post-OGTT insulin levels; HOMA-β: β-cell function; HOMA-IR: homeostasis model assessments of insulin resistance; ΔI30/ΔG30/IR: the ratio of ΔI30/ΔG30 to HOMA-IR; ΔI120/ΔG120/IR: the ratio of ΔI120/ΔG120 to HOMA-IR; AUCi: area under the curve for insulin; AUCi/IR: the ratio of AUCi to HOMA-IR.