MicroRNA and Microvascular Complications of Diabetes

Table 2

MicroRNAs Involved in Diabetic Retinopathy.

miRNA	Source	Model	miRNA levels	Putative targets	Pathogenic role	Reference
126	Retinas	STZ-DM rats, OIR mice	↓	VCAM-1 VEGF	↑ angiogenesis	[15–17]
200b	Retinas	STZ-DM rats and DM patients	↓	VEGF	↑ angiogenesis	[20]
	Vitreous	Patients with PDR, Akita-DR mice, STZ-DM mice	↑	Oxr1; Snail1; Smad2; p300	↑ EMT	[98–100]
15a	Retinas; RPE cells	STZ-DM mice and STZ-DM rats, HRPE cells	↓	VEGF-A; ASM	↑ angiogenesis, ↑ inflammation, ↑ lipotoxicity	[21]
150	Retinas	STZ-DM rats; HFD-DM mice (WT and miR-150^−/−)	↓	VEGFR2	↑ angiogenesis	[22, 23]
184	Retinas	OIR mice	↓	Frizzled-7	↑ angiogenesis	[24]
155	Retinas	OIR mice	↑	SHIP1	↑ angiogenesis	[26]
146a	Retinas	STZ-DM rats	↓	CARD10; IRAK1/2 TRAF6	↑ inflammation	[22, 34]
	Retinas	STZ-DM rats and db/db mice	↓	Fibronectin	↑ fibrosis	[30]
21	Retinas	STZ-DM rats and db/db mice	↑	PPARα	↑ inflammation	[22, 41]
195	Retinas	STZ-DM rats	↑	SIRT1	↑ apoptosis	[62]
29b	Retinas	STZ-DM mice, STZ-DM rats	↓	Sp1	↑ apoptosis	[39, 52]

RPE: retinal pigment epithelial cells; STZ: streptozotocin; OIR: oxygen-induced retinopathy; DM: diabetes; PDR: proliferative diabetic retinopathy; HFD: high-fat diet; WT: wild type; EMT: epithelial mesenchymal transition.