MicroRNA and Microvascular Complications of Diabetes

Table 3

MicroRNAs involved in diabetic neuropathy.

miRNA	Source	Model	miRNA levels	Putative targets	Pathogenic role	Reference
146	Sciatic nerve	db/db mice	↓	IRAK1/2 TRAF6	↑ inflammation, apoptosis	[31, 32]
		STZ-DM rats	↑	IRAK1/2 TRAF6	Dysfunctional NF-кB-miR-146a negative feedback loop	[27]
let-7i	DRG neurons	STZ-DM mice	↓	—	↓ neurotrophism regeneration	[51]
29b	DRG neurons	STZ-DM rats	↓	Sp1 (?)	↑ apoptosis, ↓ regeneration	[40]
29c	DRG neurons, sciatic nerve, and foot pad tissues	db/db mice	↑	PRKCI	↓ axonal growth	[53]
341	DRG neurons	STZ-DM mice	↑	—	Unknown	[51]

DRG: dorsal root ganglia; STZ: streptozotocin; DM: diabetic.