Review Article

PTH1R-CaSR Cross Talk: New Treatment Options for Breast Cancer Osteolytic Bone Metastases

Figure 1

Interplay between PTH1R and CaSR plays critical roles in the pathogenesis of BrCa bone metastases. Numbers in parentheses indicate the event sequence during the formation of BrCa bone metastases. Treatment targets shown in red are likely to inhibit BrCa proliferation, increase osteoblast bone formation, and/or decrease osteoclast bone resorption.