Elevated and Correlated Expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in Human Abdominal Adipose Tissue Play a Role in Adiposity and Insulin Resistance

Table 1

Demographic and clinical characteristics of the study cohorts.

	Level	ND lean ()	ND with obesity ()	T2DM with obesity ()
Age (median [IQR])		21 [20, 23]	26 [22, 27]	52 [51, 56]	0.004
Gender (%)	F	2 (28.6)	1 (20.0)	4 (80.0)	0.106
	M	5 (71.4)	4 (80.0)	1 (20.0)
Ethnicity (%)	AA	2 (28.6)	3 (60.0)	3 (60.0)	0.636
	Asian	1 (14.3)	0 (0.0)	0 (0.0)
	Caucasian	4 (57.1)	2 (40.0)	2 (40.0)
BMI (median [IQR])		21.70 [21.30, 22.70]	31.50 [31.15, 31.70]	32.40 [29.30, 32.90]	0.002
Waist-to-hip ratio (median [IQR])		0.80 [0.75, 0.80]	0.90 [0.90, 0.90]	0.90 [0.90, 0.90]	0.027
% fat (median [IQR])		18.45 [14.80, 22.77]	31.56 [22.51, 32.04]	34.04 [33.45, 45.30]	0.005
VO2 max (ml kg min) (median [IQR])		41.51 [34.46, 41.58]	21.73 [21.18, 22.29]	20.09 [18.03, 22.37]	0.023
GDR FFM (median [IQR])		10.84 [10.12, 12.66]	5.41 [5.09, 7.12]	6.02 [2.84, 6.76]	0.022
Glucose (median [IQR])		88.25 [87.75, 89.38]	87.00 [84.50, 92.00]	130.50 [126.00, 156.50]	0.006
Insulin (median [IQR])		4.28 [3.73, 5.24]	10.60 [10.30, 11.10]	16.10 [12.75, 31.80]	0.007
HOMA-IR (median [IQR])		0.93 [0.80, 1.11]	2.13 [2.07, 2.36]	5.14 [3.40, 11.15]	0.003

Comparison between groups for continuous variables was done using the Wilcoxon test. Comparison for categorical variables was done using the Fisher exact test. Data is presented as median with [interquartile range (IQR)] or as percent (%). ND: subjects without diabetes; T2DM: subjects with type 2 diabetes mellitus; BMI: body mass index; GDR: glucose disposal rate. Percent body fat was measured by DXA. Glucose disposal rate was measured by hyperinsulinemic-euglycemic clamp to calculate insulin resistance. VO2 max was a measure of aerobic exercise capacity. The clinical data and tissue angiogenesis were previously described [5].