International Journal of Endocrinology / 2018 / Article / Tab 1

Research Article

Elevated and Correlated Expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in Human Abdominal Adipose Tissue Play a Role in Adiposity and Insulin Resistance

Table 1

Demographic and clinical characteristics of the study cohorts.

LevelND lean ()ND with obesity ()T2DM with obesity ()

Age (median [IQR])21 [20, 23]26 [22, 27]52 [51, 56]0.004
Gender (%)F2 (28.6)1 (20.0)4 (80.0)0.106
M5 (71.4)4 (80.0)1 (20.0)
Ethnicity (%)AA2 (28.6)3 (60.0)3 (60.0)0.636
Asian1 (14.3)0 (0.0)0 (0.0)
Caucasian4 (57.1)2 (40.0)2 (40.0)
BMI (median [IQR])21.70 [21.30, 22.70]31.50 [31.15, 31.70]32.40 [29.30, 32.90]0.002
Waist-to-hip ratio (median [IQR])0.80 [0.75, 0.80]0.90 [0.90, 0.90]0.90 [0.90, 0.90]0.027
% fat (median [IQR])18.45 [14.80, 22.77]31.56 [22.51, 32.04]34.04 [33.45, 45.30]0.005
VO2 max (ml kg min) (median [IQR])41.51 [34.46, 41.58]21.73 [21.18, 22.29]20.09 [18.03, 22.37]0.023
GDR FFM (median [IQR])10.84 [10.12, 12.66]5.41 [5.09, 7.12]6.02 [2.84, 6.76]0.022
Glucose (median [IQR])88.25 [87.75, 89.38]87.00 [84.50, 92.00]130.50 [126.00, 156.50]0.006
Insulin (median [IQR])4.28 [3.73, 5.24]10.60 [10.30, 11.10]16.10 [12.75, 31.80]0.007
HOMA-IR (median [IQR])0.93 [0.80, 1.11]2.13 [2.07, 2.36]5.14 [3.40, 11.15]0.003

Comparison between groups for continuous variables was done using the Wilcoxon test. Comparison for categorical variables was done using the Fisher exact test. Data is presented as median with [interquartile range (IQR)] or as percent (%). ND: subjects without diabetes; T2DM: subjects with type 2 diabetes mellitus; BMI: body mass index; GDR: glucose disposal rate. Percent body fat was measured by DXA. Glucose disposal rate was measured by hyperinsulinemic-euglycemic clamp to calculate insulin resistance. VO2 max was a measure of aerobic exercise capacity. The clinical data and tissue angiogenesis were previously described [5].

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