International Journal of Endocrinology

Research Article

Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes

Table 1

Characteristics of study subjects based on obesity and metabolic health phenotype.


	Nonobese				Obese
	MHNW ()	MANW ()		MHO ()	MAO ()

Age (years)	53 (48, 57)	55 (52, 57)	0.165			0.778
Sex (M : F)	91 : 54	13 : 10	0.567	41 : 18	45 : 18	0.815
Waist circumference (cm)			<0.001	86 (82, 91)	90 (87, 94)	<0.001
Current smoker (n, %)	28 (19.3)	8 (34.8)	0.105	9 (15.3)	18 (28.6)	0.077
Alcohol (n, %)	79 (54.5)	10 (43.5)	0.326	32 (54.2)	33 (52.4)	0.837
SBP (mmHg)	113 (103, 122)	125 (117, 141)	<0.001			<0.001
DBP (mmHg)			<0.001			0.012
Hemoglobin (g/dL)			0.353	14.3 (13.4, 15.0)	14.8 (13.7, 15.4)	0.065
WBC (10³/μL)	5.3 (4.4, 6.3)	5.9 (5.1, 7.0)	0.034	6.0 (4.8, 6.8)	6.1 (5.4, 7.2)	0.249
Platelet count (10³/μL)	206 (184, 229)	239 (190, 262)	0.033			0.367
BUN (mg/dL)	14.2 (12.4, 17.0)	13.6 (12.5, 16.5)	0.949	15.0 (12.2, 18.3)	15.5 (11.9, 16.9)	0.417
Creatinine (mg/dL)	0.8 (0.6, 0.9)	0.7 (0.6, 0.9)	0.693	0.8 (0.6, 0.9)	0.8 (0.7, 0.9)	0.307
eGFR (mL/min/1.73 m²)	102.7 (95.8, 107.8)	101.1 (95.4, 105.9)	0.124	100.2 (95.9, 104.9)	96.6 (89.7, 106.4)	0.252
Total bilirubin (mg/dL)	0.7 (0.6, 1.0)	0.7 (0.5, 1.1)	0.782	0.8 (0.6, 0.9)	0.7 (0.6, 0.9)	0.234
Albumin (g/dL)	4.4 (4.2, 4.5)	4.4 (4.2, 4.5)	0.247	4.3 (4.3, 4.5)	4.4 (4.3, 4.5)	0.027
AST (IU/L)	23 (20, 31)	27 (21, 36)	0.128	26 (22, 34)	29 (23, 43)	0.038
ALT (IU/L)	19 (15, 27)	27 (23, 38)	0.004	23 (17, 38)	32 (20, 50)	0.030
hsCRP (mg/L)	4 (2, 12)	11 (3, 19)	0.113	6 (3, 17)	9 (4, 23)	0.259
Glucose (mg/dL)	95 (88, 101)	105 (99, 109)	<0.001	95 (91, 99)	106 (101, 126)	<0.001
LDL cholesterol (mg/dL)	116 (100, 141)	138 (111, 158)	0.010	134 (108, 155)	109 (83, 145)	0.004
HDL cholesterol (mg/dL)	55 (46, 67)	45 (37, 50)	<0.001	51 (44, 58)	44 (37, 50)	0.001
Triglyceride (mg/dL)	87 (63, 125)	164 (95, 196)	<0.001	111 (74, 147)	187 (122, 269)	<0.001
Mean baPWV (m/sec)	13.1 (12.0, 14.4)	13.9 (13.0, 16.8)	0.005	13.1 (11.9, 14.3)	13.7 (12.8, 15.4)	0.025
Mean CIMT (mm)	0.7 (0.6, 0.7)	0.7 (0.6, 0.7)	0.392	0.7 (0.6, 0.7)	0.7 (0.6, 0.7)	0.904

MHNW: metabolically healthy normal weight; MANW: metabolically abnormal but normal weight; MHO: metabolically healthy obesity; MAO: metabolically abnormal obesity; SBP: systolic blood pressure; DBP: diastolic blood pressure; WBC: white blood cell count; BUN: blood urea nitrogen; eGFR: estimate glomerular filtration rate; AST: aspartate aminotransferase; ALT: alanine aminotransferase; hsCRP: high-sensitivity C-reactive protein; LDL: low-density lipoprotein; HDL: high-density lipoprotein; baPWV: brachial-ankle pulse wave velocity; CIMT: carotid intima-media thickness.