Relationship of Circulating Fetuin-A Levels with Body Size and Metabolic Phenotypes

Table 3

Multivariate logistic regression analysis for the risk of metabolic abnormal according to the tertiles of fetuin-A concentrations in individuals without obesity (a) and with obesity (b).

(a)

	T1	T2	T3	for trend
No of cases/references	2/54	8/48	13/43
Cutoff of fetuin-A (μg/mL)	330.7-544.2	545.0-679.3	679.4-1316.8
Model 1	1	3.91 (0.72, 21.34)	10.81 (2.05, 56.96)	0.002
Model 2	1	4.95 (0.78, 31.40)	10.03 (1.66, 60.81)	0.009
Model 3	1	9.14 (1.21, 69.05)	12.90 (1.83, 90.80)	0.011
Model 4	1	8.30 (1.08, 63.72)	12.75 (1.62, 100.49)	0.017

(b)

	T1	T2	T3	for trend
No of cases/references	15/25	24/17	24/17
Cutoff of fetuin-A (μg/mL)	372.5-594.2	595.5-764.5	784.3-1572.3
Model 1	1	2.57 (1.00, 6.59)	2.53 (0.96, 6.66)	0.056
Model 2	1	3.48 (1.26, 9.64)	2.99 (1.07, 8.37)	0.036
Model 3	1	4.48 (1.43, 14.06)	3.44 (1.06, 11.18)	0.036
Model 4	1	4.22 (1.32, 13.52)	3.77 (1.13, 12.60)	0.028

Model 1: adjusted for age, sex, and body mass index (BMI); model 2: adjusted for model 1 + smoking, alcohol, and estimate glomerular filtration rate (eGFR); model 3: adjusted for model 2 + aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin, and albumin; model 4: adjusted for model 3 + white blood cell count, hemoglobin, and platelet count.