Research Article

Free Testosterone Reflects Metabolic as well as Ovarian Disturbances in Subfertile Oligomenorrheic Women

Table 3

Associations between androgens and SHBG and metabolic and ovarian parameters.

AdjustmentsTotal TA4Free TSHBG

BMIUnadjusted1.061.172.09−2.89
(−0.13, 2.24)(−0.001, 2.34)(0.98, 3.19)(−4.16, −1.61)
Age1.061.172.12−2.92
(−0.13, 2.25)(−0.01, 2.35)(1.00, 3.23)(−4.21, −1.64)

GlucoseUnadjusted0.070.250.02−1.50
(−1.68, 1.81)(−1.50, 1.99)(−0.02, 0.06)(−3.64, 0.65)
Age and BMI−0.19−0.010.01−0.90
(−1.95, 1.57)(−1.78, 1.76)(−0.03, 0.05)(−3.40, 1.61)

InsulinUnadjusted3.894.530.01−19.39
(−5.67, 13.45)(−4.98, 14.04)(0.002, 0.02)(−30.20, −8.58)
Age and BMI−0.79−0.630.001−5.52
(−8.33, 6.76)(−8.19, 6.94)(−0.007, 0.01)(−16.16, 5.13)

HOMA-IRUnadjusted0.080.090.48−0.36
(−0.10, 0.25)(−0.09, 0.27)(0.10, 0.85)(−0.55, −0.16)
Age and BMI−0.010.0010.11−0.10
(−0.14, 0.13)(−0.14, 0.14)(−0.38, 0.60)(−0.29, 0.09)

Total cholesterolUnadjusted9.957.220.011.92
(3.56, 16.33)(0.64–13.80)(0.001, 0.02)(−6.35, 10.20)
Age and BMI8.906.000.018.19
(2.41, 15.38)(−0.70, 12.71)(−0.003, 0.01)(−0.95, 17.31)

HDL cholesterolUnadjusted1.240.09−0.014.65
(−2.03, 4.52)(−3.19, 3.37)(−0.03, 0.01)(0.84, 8.47)
Age and BMI1.880.80−0.0044.42
(−1.27, 5.03)(−2.39, 3.98)(−0.02, 0.01)(0.22, 8.62)

LDL cholesterolUnadjusted7.175.960.010.08
(1.66, 12.67)(0.39, 11.52)(0.001, 0.02)(−6.93, 7.08)
Age and BMI6.014.670.015.51
(0.45, 11.57)(−0.98, 10.32)(−0.004, 0.02)(−2.23, 13.25)

TriglyceridesUnadjusted7.695.880.01−14.03
(−3.78, 19.17)(−5.62, 17.37)(0.001, 0.01)(−27.68, −0.39)
Age and BMI5.042.650.005−8.70
(−6.04, 16.12)(−8.50, 13.80)(−0.0004, 0.01)(−23.76, 6.35)

AMHUnadjusted0.080.080.06−0.01
(0.03, 0.12)(0.03, 0.12)(0.02, 0.11)(−0.05, 0.03)
Age and BMI0.070.080.06−0.01
(0.03, 0.12)(0.03, 0.12)(0.02, 0.10)(−0.05, 0.03)

Ovarian volumeUnadjusted0.150.170.16−0.05
(0.09, 0.22)(0.11, 0.23)(0.09, 0.22)(−0.11, 0.01)
Age and BMI0.150.170.14−0.03
(0.08, 0.21)(0.11, 0.23)(0.08, 0.20)(−0.09, 0.02)

AFCUnadjusted0.040.050.04−0.01
(0.03, 0.06)(0.03, 0.06)(0.02, 0.05)(−0.03, 0.005)
Age and BMI0.040.050.04−0.01
(0.03, 0.06)(0.03, 0.06)(0.02, 0.05)(−0.02, 0.003)

Linear regression with adjustments for age and BMI. Data are reported as coefficients with 95% confidence interval per standard deviation increase in androgen/SHBG. , , . T: testosterone; A4: androstenedione; SHBG: sex hormone-binding globulin; BMI: body mass index; HOMA-IR: homeostasis model assessment of insulin resistance; AMH: anti-Mullerian hormone; AFC: antral follicle count.