International Journal of Endocrinology / 2018 / Article / Tab 1

Clinical Study

Emergence of Pituitary Adenoma in a Child during Surveillance: Clinical Challenges and the Family Members’ View in an AIP Mutation-Positive Family

Table 1

Biochemical evaluation of the somatotrope and prolactin axes in the proband’s brother (case 2), at diagnosis, postoperatively, and during follow-up. TSS: transsphenoidal surgery; ×ULN: times above the upper limit of normal.

Date of biochemical evaluationIGF-1Normal rangeProlactinNormal rangeGH on OGTT
0–30–60–90–120–150

February 2002
Preoperatively
75.3 (1.2 × ULN)29–64 nmol/L92745–375 mU/L2.0–0.4–0.8–0.5–0.5 μg/L
August 2002
Six months postoperatively
34.7
(0.5 × ULN)
29–64 nmol/L239
2002–2009Results not available
May 2009317
(0.8 × ULN)
117–358 ng/mL193<496 mU/L1.4–1.0–0.82–0.74–1.4–2.4 μg/L
October 2009
On short-acting octreotide (100 μg three times a day)
266
(0.7 × ULN)
117–358 ng/mL261<496 mU/L0.96–1.1–1.2–1.2–1.3 μg/L
November 2010389
(1.1 × ULN)
117–358 ng/mL298<496 mU/L
December 2010168
(0.5 × ULN)
117–358 ng/mL260<496 mU/L
July 2011348
(1.0 × ULN)
117–358 ng/mL256<496 mU/L
December 2012326
(0.9 × ULN)
117–358 ng/mL<496 mU/L1.9–1.36–1.12–1.24–1.45–1.59 μg/L
May 2014398
(1.3 × ULN)
125–302 μg/L297<496 mU/L
October 2015303
(1.0 × ULN)
125–302 μg/L313<324 mU/L
October 2016326
(1.4 × ULN)
82.5–240.4 μg/L353<324 mU/L3.41–3.17–2.53–2.59–2.91–2.87 μg/L
GH day curve over 10 hours
3.12 μg/L, 1.93 μg/L, 2.05 μg/L, 3.23 μg/L, 2.61 μg/L. Mean GH = 2.59 μg/L
January 2017
On lanreotide
320
(1.3 × ULN)
82.5–240.4 μg/L
February 2017
On lanreotide
280
(1.2 × ULN)
82.5–240.4 μg/L
August 2017
Two months after the second TSS
112
(0.5 × ULN)
82.5–240.4 μg/L
September 201793
(0.4 × ULN)
82.5–240.4 μg/L161<324 mU/L0.41–0.34–0.32–0.30–0.25–0.41 μg/L

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