Emergence of Pituitary Adenoma in a Child during Surveillance: Clinical Challenges and the Family Members’ View in an AIP Mutation-Positive Family
Table 1
Biochemical evaluation of the somatotrope and prolactin axes in the proband’s brother (case 2), at diagnosis, postoperatively, and during follow-up. TSS: transsphenoidal surgery; ×ULN: times above the upper limit of normal.
Date of biochemical evaluation
IGF-1
Normal range
Prolactin
Normal range
GH on OGTT 0–30–60–90–120–150
February 2002 Preoperatively
75.3 (1.2 × ULN)
29–64 nmol/L
927
45–375 mU/L
2.0–0.4–0.8–0.5–0.5 μg/L
August 2002 Six months postoperatively
34.7 (0.5 × ULN)
29–64 nmol/L
239
2002–2009
Results not available
May 2009
317 (0.8 × ULN)
117–358 ng/mL
193
<496 mU/L
1.4–1.0–0.82–0.74–1.4–2.4 μg/L
October 2009 On short-acting octreotide (100 μg three times a day)
266 (0.7 × ULN)
117–358 ng/mL
261
<496 mU/L
0.96–1.1–1.2–1.2–1.3 μg/L
November 2010
389 (1.1 × ULN)
117–358 ng/mL
298
<496 mU/L
December 2010
168 (0.5 × ULN)
117–358 ng/mL
260
<496 mU/L
July 2011
348 (1.0 × ULN)
117–358 ng/mL
256
<496 mU/L
December 2012
326 (0.9 × ULN)
117–358 ng/mL
<496 mU/L
1.9–1.36–1.12–1.24–1.45–1.59 μg/L
May 2014
398 (1.3 × ULN)
125–302 μg/L
297
<496 mU/L
October 2015
303 (1.0 × ULN)
125–302 μg/L
313
<324 mU/L
October 2016
326 (1.4 × ULN)
82.5–240.4 μg/L
353
<324 mU/L
3.41–3.17–2.53–2.59–2.91–2.87 μg/L GH day curve over 10 hours 3.12 μg/L, 1.93 μg/L, 2.05 μg/L, 3.23 μg/L, 2.61 μg/L. Mean GH = 2.59 μg/L
