Age-Related Cutoffs of Plasma Aldosterone/Renin Concentration for Primary Aldosteronism Screening
Table 2
Characteristics of patients in different age subgroups.
Essential hypertension ()
for trend
Primary aldosteronism ()
for trend
Age < 40 y ()
Age 40–49 y ()
Age 50–59 y ()
Age ≥ 60 y ()
Age < 40 y ()
Age 40–49 y ()
Age 50–59 y ()
Age ≥ 60 y ()
Gender (M/F)
66/40
29/33
31/33
23/56
0.000
13/26
30/26
22/17
17/23
0.133
APA (, %)
—
—
—
—
—
13/26
25/31
20/19
23/17
0.165
Age (years)
31.31 ± 5.51
44.81 ± 3.18
53.86 ± 3
67.27 ± 5.78
0.000
32.15 ± 4.73
45.04 ± 2.94
54.18 ± 2.73
65.85 ± 4.22
0.000
SBP (mmHg)
155.18 ± 20.25
154.31 ± 21.41
152.06 ± 23.26
149.76 ± 21.85
0.359
158.03 ± 22.01
158.56 ± 21.13
160.23 ± 16.8
150.94 ± 21.49
0.192
DBP (mmHg)
100.7 ± 16.03
98.42 ± 11.23
92.41 ± 12.51
81.57 ± 12.83
0.000
104.9 ± 13.47
98.91 ± 14.88
95.88 ± 11.18
85.26 ± 15.24
0.000
BMI (kg/m2)
26.45 (23.03, 29.05)
25.54 (23.19, 27.34)
25.1 (22.96, 27.92)
24.09 (21.93, 25.91)
0.001
23.83 (21.22, 26.22)
24.51 (22.87, 27.19)
24.62 (22.83, 26.95)
24.27 (21.65, 26.45)
0.347
Serum K+ (mmol/l)
4 (3.8, 4.3)
4 (3.8, 4.3)
4 (3.8, 4.18)
4.1 (3.65, 4.3)
0.787
2.9 (2.7, 3.6)
3.25 (2.73, 3.8)
3.2 (2.8, 3.6)
3.1 (2.8, 3.7)
0.754
Serum Na+ (mmol/l)
141 (139, 143)
142 (140, 144)
142 (140, 144)
142 (140, 143)
0.211
142 (141, 145)
143 (142, 145)
143 (142, 146)
143 (141, 145)
0.374
24 h urinary Na+ (mmol)
130 (91.45, 182.35)
150.4 (101.45, 221.45)
148.65 (110.58, 207.25)
145.6 (96.6, 229.9)
0.262
171 (128.95, 223.8)
168.5 (110.85, 251.18)
150.6 (124.8, 188.1)
124.45 (89.05, 175.63)
0.023
24 h Urinary K+ (mmol)
34 (26.15, 44.9)
33 (25.43, 47.85)
28.7 (22.13, 44.14)
34.3 (27.2, 45.43)
0.422
46 (28.95, 66.45)
54.4 (35.55, 81.33)
51.4 (37.6, 64.5)
49.35 (31.25, 71.48)
0.567
Data were expressed as mean ± SD, %, or median (interquartile range). APA: aldosterone producing adenoma; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; serum K+: concentration of serum potassium; serum Na+: concentration of serum sodium. compared with corresponding PA subgroup.
