Magnesium and Human Health: Perspectives and Research Directions

Table 7

Medications associated with hypomagnesemia.

Medications	System	Pathophysiology
Aminoglycoside antibiotics	Renal	Impair renal tubular reabsorption ± acute tubular necrosis (ATN)
Amphotericin B	Renal	Renal toxicity and impaired magnesium reabsorption
Antiepidermal growth factor (EGF) receptor (e.g., cetuximab)	Renal	Impairs magnesium reabsorption
Calcineurin inhibitors (e.g., cyclosporine and tacrolimus)	Renal	Impair magnesium reabsorption
Platinum derivatives (e.g., cisplatin and carboplatin)	Renal	Impair magnesium reabsorption
Loop and thiazide diuretics	Renal	Impair magnesium reabsorption
Pentamidine	Renal	Impairs magnesium reabsorption
Proton pump inhibitors (PPI)	GI	Reduce intestinal absorption of magnesium by downregulating the TRPM6 transporters.

GI: gastrointestinal.