|
| Author/Journal and year | Participants | Results | Comments |
|
| Palma-Duran et al., Metabolism, 2018 Jun. [67] | 50 normoglycemic NAFLD and 58 healthy adults (age, sex, and BMI matched) | Elevated AGEs/sRAGE ratio was associated with NAFLD | AGEs (CML) higher, sRAGE levels lower, and AGEs/sRAGE ratios were higher in the NAFLD |
| Mehta et al., PLoS One, 2018 Jun. [68] | 340 obese patients with metabolic syndrome | Certain polymorphisms of RAGE gene are indicators of NASH in obese people | Retrospective study |
| Only four polymorphisms were tested |
| Zelber-Sagi et al., Dig Liver, Dis, 2017 May [63] | 55 patients with fatty liver diagnosed by ultrasound (age 26–64) | sRAGE levels have negative correlation with liver damage | Serum sRAGE levels have negative association with fatty liver and positive correlation with fiber and vegetables consumption |
| Kan et al., J Clin Lab Anal, 2015 Nov. [69] | 90 NBNC-HCC | AGE could discriminate NBNC-HCC from NASH | NBNC-HCC patients had higher serum levels of AGE, compared to the NASH and control subjects |
| 56 NASH |
| 27 control subjects |
| Santilli et al., Vascular Pharmacology, 2015 Sep. [70] | 110 patients with FCHL, MS, and both FCHL plus MS | NAFLD patients had significantly lower plasma esRAGE irrespective of underlying metabolic abnormality (FCHL or MS) | Cross-sectional study |
| Lower levels of IL-10 and adiponectin and higher CD40 ligand, endogenous thrombin potential, and oxidized LDL in NAFLD patients |
| Su et al., Medicine (Baltimore), 2015 Aug. [71] | 300 cancer-free cases | SNP rs1800625 of RAGE gene increases risk of HCC but has an inverse association with HCC progression | 5 common polymorphisms of RAGE gene were tested |
| 265 HCC patients |
| D’Adamo et al., Free Radic Res, 2013 Mar. [72] | Obese prepubertal children with NAFLD | Vitamin E supplementation increased the levels of esRAGE after 6-month treatment | Vitamin E could potentially be a treatment in obese children with NAFLD |
| (i) 24 children received vitamin E supplementation | Vitamin E supplementation decreased oxidative stress and improved cardiometabolic alterations |
| (ii) 21 age- and sex-matched received life-style intervention |
| Gaens et al., Journal of Hepatology, 2012 Mar. [73] | 74 obese individuals | CML and CML upregulated RAGE-dependent inflammatory response associated with NAFLD | In vitro model of steatosis used |
| CML accumulation associated with increased gene expression of proinflammatory cytokines |
| D’Adamo et al., Antioxidants and Redox signaling, 2011 Mar. [74] | 140 prepubertal obese children | esRAGE and sRAGE levels were significantly lower in obese prepubertal children affected by liver steatosis compared with the group without liver steatosis | Definition of liver steatosis by ultrasound instead of the gold-standard invasive liver biopsy |
| 71 boys and 69 girls aged between 6 and 10 years |
| Kimura et al., J Gastroenterol, 2010 Jul. [75] | 43 patients with dyslipidemia and biopsy-proven NASH | Atorvastatin reduces the serum levels of AGEs | AGEs are useful biomarkers for the attenuation of NASH |
| Yilmaz et al., Clin Biochem, 2009 Jun. [76] | 40 NASH | Patients with NASH (definite and borderline) had lower plasma levels of sRAGE |
| 8 borderline NASH |
| 9 simple fatty liver |
| 14 healthy controls |
| Hyogo et al., J Gastroenterol Hepatol, 2007 Jul. [77] | 66 NASH | The serum glyceraldehyde-derived AGE level may be a useful biomarker for NASH | Constant increase in glyceraldehyde-derived AGEs could potentially contribute to the pathogenesis of NASH |
| 10 simple steatosis |
| 30 controls |
|
