Comparative Proteomic Analysis of Visceral Adipose Tissue in Morbidly Obese and Normal Weight Chinese Women

Table 3

Top canonical pathways and related differential proteins.

Ingenuity canonical pathways	−log ( value)	z-score	Proteins
LXR/RXR activation	7.54	−1.342	C4A/C4B, LYZ, ECHS1, APOB, FASN, ACACA, S100A8, MMP9, HADH
Fatty acid β-oxidation I	4.57	NaN	ECHS1, ECI1, ACSL1, HADH
Valine degradation I	3.87	NaN	ECHS1, BCKDHA, ALDH6A1
TCA cycle II (eukaryotic)	3.54	NaN	CS, SUCLG1, MDH2
Creatine-phosphate biosynthesis	3.50	NaN	CKB, CKM
Mitochondrial dysfunction	3.37	NaN	PDHA1, NDUFA4, CYCS, DHODH, ATP5I, UQCRB
Intrinsic prothrombin activation pathway	3.24	NaN	COL1A2, FGB, FGG
Acetyl-CoA biosynthesis I (pyruvate dehydrogenase complex)	3.18	NaN	PDHA1, PDHB
Atherosclerosis signaling	3.16	NaN	COL1A2, LYZ, APOB, S100A8, MMP9
Ethanol degradation II	3.07	NaN	ALDH1B1, ADH1B, ACSL1
Stearate biosynthesis I (animals)	2.96	NaN	FASN, ACOT1, ACSL1
Role of IL-17A in psoriasis	2.62	NaN	S100A9, S100A8
Acute-phase response signaling	2.56	2	C4A/C4B, FTL, FN1, FGB, FGG

z-score was to infer the activation state of pathways. Positive z-score represented that the pathway was activated; negative z-score indicated that the pathway was suppressed.