Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study

Figure 6

The proposed mechanism by which HBOT affects regulation of iNOS activity/expression and nitrite/nitrate production in T1DM patients. iNOS: inducible nitric oxide synthase; NFκB-p65: the p65 subunit of nuclear factor-κB; NO: nitric oxide; ERK1/2: extracellular signal-regulated kinases 1 and 2; Akt: protein kinase B; CRP: C-reactive protein; FFA: free fatty acid. Other abbreviations are under Table 1.