miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling

Figure 4

Effects of miR-29a and Cdc42 on β-catenin expression. (a) Effects of miR-29a on β-catenin expression. Western blot to detect β-catenin expression after transfection with miR-29a mimic and inhibitor (n = 3). , compared with miR-29a mimic NC, and , compared with miR-29a inhibitor NC, as assessed by paired Student’s t-test. (b) Effects of Cdc42 on β-catenin expression. Western blot to detect β-catenin expression after transfection with Cdc42-pcDNA3.1 and siRNA-643 (n = 3). , compared with pcDNA3.1, and , compared with siRNA-NC, as assessed by paired Student’s t-test. Data are shown as mean ± SD. NC: negative control.

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