Review Article

Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review

Table 1

Diagnostic criteria for IgG4-related hypophysitis.

1. Histopathology mononuclear infiltration of the pituitary gland, rich in lymphocytes and plasma cells, with more than 10 IgG4-positive cells per high-power field
2. Sellar mass and/or thickened pituitary stalk on pituitary MRI
3. Biopsy-proven involvement in other organs (association with IgG4-positive lesions in other organs)
4. Elevated serum IgG4 levels (>140 mg/dl)
5. Rapidly reduction of the pituitary mass and symptom improvement with steroids
When any of the following is fulfilled, criterion 1 only, criteria 2 + 3, or criteria 2 + 4 + 5.